GCK protein (Homo sapiens) - STRING interaction network

GCK protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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	GCK	Glucokinase (EC 2.7.1.2) (Hexokinase-4) (Hexokinase type IV) (HK IV) (HK4) (Hexokinase-D); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (466 aa)
		(Homo sapiens)
Predicted Functional Partners:
	HNF4A	Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Transcription factor HNF-4) (Transcription fac [...] (496 aa)		•	•	0.995
	PDX1	Pancreas/duodenum homeobox protein 1 (PDX-1) (Insulin promoter factor 1) (IPF-1) (Islet/duodenu [...] (283 aa)		•	•	0.995
	SLC2A2	Solute carrier family 2, facilitated glucose transporter member 2 (Glucose transporter type 2, [...] (524 aa)		•	•	0.988
	INS	Insulin precursor [Contains- Insulin B chain; Insulin A chain]; Insulin decreases blood glucose [...] (110 aa)	•		•	0.985
	GCKR	Glucokinase regulatory protein (Glucokinase regulator); Inhibits glucokinase by forming an inac [...] (625 aa)	•		•	0.983
	FOXO1A	Forkhead box protein O1A (Forkhead in rhabdomyosarcoma); Transcription factor (655 aa)		•	•	0.973
	FOXA2	Hepatocyte nuclear factor 3-beta (HNF-3B) (Forkhead box protein A2); Transcription activator fo [...] (457 aa)		•	•	0.972
	GPI	Glucose-6-phosphate isomerase (EC 5.3.1.9) (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexos [...] (558 aa)		•	•	0.967
	ALDOB	Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) (364 aa)		•	•	0.966
	TCF1	Hepatocyte nuclear factor 1-alpha (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) ( [...] (631 aa)			•	0.960

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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