aceK protein (Citrobacter koseri) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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	aceK	Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) (575 aa)
		(Citrobacter koseri)
Predicted Functional Partners:
	CKO_03905	Putative uncharacterized protein (439 aa)	•		•		•	0.846
	CKO_03906	Putative uncharacterized protein (533 aa)	•				•	0.793
	icd	Isocitrate dehydrogenase [NADP] (416 aa)	•	•			•	0.746
	CKO_02000	Putative uncharacterized protein (227 aa)		•				0.664
	proQ	ProP effector; Not exactly known; may be a structural element that influences the osmotic activ [...] (228 aa)		•				0.653
	CKO_03241	hypothetical protein (220 aa)	•					0.624
	CKO_03165	Putative uncharacterized protein (188 aa)	•			•		0.618
	CKO_03675	Putative uncharacterized protein (1100 aa)		•				0.618
	CKO_01890	Putative uncharacterized protein (81 aa)		•				0.609
	CKO_00060	Putative uncharacterized protein (221 aa)	•			•		0.597

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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