STRINGSTRING
Letmd1 Letmd1 Lmbr1 Lmbr1 Ubxn1 Ubxn1 Eif2d Eif2d Mycbp Mycbp Mrto4 Mrto4 Plekhg2 Plekhg2 Nol7 Nol7 Heatr3 Heatr3 Tmem74 Tmem74 B3galnt2 B3galnt2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Letmd1LETM1 domain-containing 1. (371 aa)    
Predicted Functional Partners:
Lmbr1
Limb development membrane protein 1; Belongs to the LIMR family.
    
 
 0.644
Ubxn1
UBX domain-containing protein 1; Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'- linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1- BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (By similarity).
      
 0.600
Eif2d
Eukaryotic translation initiation factor 2D; Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its [...]
   
    0.537
Mycbp
Myc-binding protein.
      
 0.510
Mrto4
Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
      
 0.510
Plekhg2
Pleckstrin homology and RhoGEF domain-containing G2.
      
 0.506
Nol7
Nucleolar protein 7.
      
 0.497
Heatr3
HEAT repeat-containing 3.
      
 0.489
Tmem74
Transmembrane protein 74.
      
 0.474
B3galnt2
Hexosyltransferase.
      
 0.473
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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