EDA2R protein (Homo sapiens) - STRING network view

STRING 9.05

EDA2R protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	EDA2R	ectodysplasin A2 receptor; Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6 (297 aa)
		(Homo sapiens)
Predicted Functional Partners:
	TRAF6	TNF receptor-associated factor 6; Adapter protein and signal transducer that links members of t [...] (522 aa)		•		•	0.974
	EDA	ectodysplasin A; Seems to be involved in epithelial-mesenchymal signaling during morphogenesis [...] (391 aa)	•	•	•	•	0.971
	TRAF3	TNF receptor-associated factor 3; Adapter protein and signal transducer that links members of t [...] (568 aa)		•		•	0.905
	TP53	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)				•	0.827
	SLC24A5	solute carrier family 24, member 5; Cation exchanger involved in pigmentation, possibly by part [...] (500 aa)				•	0.778
	SLC45A2	solute carrier family 45, member 2; Melanocyte differentiation antigen. May transport substance [...] (530 aa)				•	0.732
	CYLD	cylindromatosis (turban tumor syndrome); Negative regulator of TRAF2 and NF-kappa-B signaling p [...] (956 aa)				•	0.675
	CXorf23	chromosome X open reading frame 23 (682 aa)	•			•	0.667
	CASP8	caspase 8, apoptosis-related cysteine peptidase; Most upstream protease of the activation casca [...] (538 aa)		•		•	0.652
	FADD	Fas (TNFRSF6)-associated via death domain; Apoptotic adaptor molecule that recruits caspase-8 o [...] (208 aa)		•			0.619

Views:

Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

required confidence (score):

interactors shown:

or custom value:

or custom limit:

additional (white) nodes

Server load: low (31%)

Permalink