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There are several matches for 'MAVS'.
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organism
protein
1)
Homo sapiens
MAVS
- Mitochondrial antiviral-signaling protein; Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial
MAVS
act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal
MAVS
induces the rapid interferon-independent expression of defense factors that [...]
2)
Homo sapiens
PCBP2 - Poly(rC)-binding protein 2; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by
MAVS
signaling. It acts as an adapter between
MAVS
and the E3 ubiquitin ligase ITCH, therefore triggering
MAVS
ubiquitination and degradation.
[a.k.a. PCBP2-213, NM_005016, CCDS8859]
3)
Homo sapiens
NLRX1 - NLR family member X1; Participates in antiviral signaling. Acts as a negative regulator of
MAVS
-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-
MAVS
interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Regulates also
MAVS
-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxy [...]
[a.k.a. NP_001269287, ENST00000409991.5, OTTHUMG00000154476]
4)
Homo sapiens
UBXN1 - UBX domain-containing protein 1; Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component
MAVS
. In turn, interferes with
MAVS
oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibi [...]
[a.k.a. UBX domain protein 1, NM_001286078.1, NM_001286077.1]
5)
Homo sapiens
TRIM14 - Tripartite motif-containing protein 14; Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with
MAVS
at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the
MAVS
signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation ; Belongs to the TRIM/RBCC family.
[a.k.a. ENST00000478401.1, ENSG00000106785, EAW58877.1]
6)
Homo sapiens
GPATCH3 - G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial
MAVS
and inhibition of
MAVS
assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6.
[a.k.a. 63906, ENST00000450844, CAD38742.1]
7)
Homo sapiens
IFIT3 - Interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances
MAVS
-mediated host antiviral responses by serving as an adapter bridging TBK1 to
MAVS
which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B [...]
[a.k.a. NP_001276688.1, IFI-60K, CIG-49]
8)
Homo sapiens
TTLL12 - Tubulin--tyrosine ligase-like protein 12; Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing
MAVS
binding to TBK1 and IKBKE.
[a.k.a. NP_055955, V9GY16, AAH01070.1]
9)
Homo sapiens
TRAFD1 - TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from
MAVS
and upstream of NF-kappa-B and IRF3 (By similarity).
[a.k.a. NP_006691, EAW97997.1, F8VWK2]
10)
Homo sapiens
RNF123 - E3 ubiquitin-protein ligase RNF123; Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter
MAVS
.
[a.k.a. NP_071347.2, 2MA6, AK022627]
11)
Homo sapiens
SMURF1 - E3 ubiquitin-protein ligase SMURF1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of
MAVS
. Plays a role in dendrite formation by melanocytes.
[a.k.a. R-HSA-170834, uc003upu.3, AF199364]
12)
Homo sapiens
WRNIP1 - ATPase WRNIP1; Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG- I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial
MAVS
.
[a.k.a. CH471087, NP_064520, WRNIP1-201]
13)
Homo sapiens
ATG16L1 - Autophagy-related protein 16-1; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. Regulates mitochondrial antiviral signaling (
MAVS
)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response. Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway. Plays a r [...]
[a.k.a. XP_006712671, ATG16L1-210, ENSP00000398773]