node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAD | BAK1 | ENSBTAP00000016610 | ENSBTAP00000000549 | BCL2 associated agonist of cell death. | Bcl-2 homologous antagonist/killer transcript variant 1. | 0.773 |
BAD | BCL2 | ENSBTAP00000016610 | ENSBTAP00000025701 | BCL2 associated agonist of cell death. | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). | 0.993 |
BAD | BID | ENSBTAP00000016610 | ENSBTAP00000040367 | BCL2 associated agonist of cell death. | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | 0.842 |
BAD | CYCS | ENSBTAP00000016610 | ENSBTAP00000007918 | BCL2 associated agonist of cell death. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.569 |
BAD | CYCT | ENSBTAP00000016610 | ENSBTAP00000031831 | BCL2 associated agonist of cell death. | Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.564 |
BAK1 | BAD | ENSBTAP00000000549 | ENSBTAP00000016610 | Bcl-2 homologous antagonist/killer transcript variant 1. | BCL2 associated agonist of cell death. | 0.773 |
BAK1 | BBC3 | ENSBTAP00000000549 | ENSBTAP00000062133 | Bcl-2 homologous antagonist/killer transcript variant 1. | Uncharacterized protein. | 0.886 |
BAK1 | BCL2 | ENSBTAP00000000549 | ENSBTAP00000025701 | Bcl-2 homologous antagonist/killer transcript variant 1. | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). | 0.993 |
BAK1 | BECN1 | ENSBTAP00000000549 | ENSBTAP00000067271 | Bcl-2 homologous antagonist/killer transcript variant 1. | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] | 0.639 |
BAK1 | BECN2 | ENSBTAP00000000549 | ENSBTAP00000055528 | Bcl-2 homologous antagonist/killer transcript variant 1. | Beclin 2. | 0.443 |
BAK1 | BID | ENSBTAP00000000549 | ENSBTAP00000040367 | Bcl-2 homologous antagonist/killer transcript variant 1. | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | 0.995 |
BAK1 | BNIP3 | ENSBTAP00000000549 | ENSBTAP00000023684 | Bcl-2 homologous antagonist/killer transcript variant 1. | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mito [...] | 0.427 |
BAK1 | CYCS | ENSBTAP00000000549 | ENSBTAP00000007918 | Bcl-2 homologous antagonist/killer transcript variant 1. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.972 |
BAK1 | CYCT | ENSBTAP00000000549 | ENSBTAP00000031831 | Bcl-2 homologous antagonist/killer transcript variant 1. | Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.970 |
BAK1 | TP53 | ENSBTAP00000000549 | ENSBTAP00000001420 | Bcl-2 homologous antagonist/killer transcript variant 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.976 |
BBC3 | BAK1 | ENSBTAP00000062133 | ENSBTAP00000000549 | Uncharacterized protein. | Bcl-2 homologous antagonist/killer transcript variant 1. | 0.886 |
BBC3 | BCL2 | ENSBTAP00000062133 | ENSBTAP00000025701 | Uncharacterized protein. | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). | 0.995 |
BBC3 | BID | ENSBTAP00000062133 | ENSBTAP00000040367 | Uncharacterized protein. | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | 0.942 |
BBC3 | CYCS | ENSBTAP00000062133 | ENSBTAP00000007918 | Uncharacterized protein. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.467 |
BBC3 | CYCT | ENSBTAP00000062133 | ENSBTAP00000031831 | Uncharacterized protein. | Cytochrome c 2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.450 |