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pmt3 pmt3 ulp1 ulp1 hus5 hus5 uba2 uba2 pli1 pli1 ulp2 ulp2 rad31 rad31 rna1 rna1 srs2 srs2 pcn1 pcn1 smc5 smc5
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene co-occurrence
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textmining
co-expression
protein homology
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pmt3Ubiquitin-like protein pmt3/smt3; Required for chromosome segregation where it may be involved in microtubule assembly. Loss of smt3 leads to an increase in telomere length; Belongs to the ubiquitin family. SUMO subfamily. (117 aa)    
Predicted Functional Partners:
ulp1
Ubiquitin-like-specific protease 1; A cysteine protease that proteolytically removes the C- terminus of pmt3.
   
 0.999
hus5
SUMO-conjugating enzyme ubc9; Catalyzes the covalent attachment of ubiquitin-like protein SUMO/Smt3 to other proteins. Required for efficient recovery from DNA damage or S-phase arrest and normal mitosis. This may be as part of a checkpoint independent recovery process; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.999
uba2
Ubiquitin-activating enzyme E1-like; The dimeric enzyme acts as a SUMO/pmt3 E1 ligase. It mediates ATP-dependent activation of pmt3 and formation of a thioester with a conserved cysteine residue on aos1 (By similarity).
   
 0.998
pli1
E3 SUMO-protein ligase pli1; Acts as an E3 ligase mediating SUMO/Smt3 attachment to other proteins. Involved in the maintenance of the centromere and in telomere length. Regulates recombination, via extension sumoylation, particularly within the heterochromatin repeats. Belongs to the PIAS family.
    
 0.998
ulp2
Ubiquitin-like-specific protease 2.
    
 
 0.996
rad31
DNA damage tolerance protein rad31; Could be involved in a ubiquitin-related process important for DNA damage tolerance. Acts in a process which is defective in the checkpoint rad mutants and which involves hus5.
   
 0.996
rna1
Ran GTPase-activating protein 1; GTPase activator for the nuclear Ras-related regulatory protein spi1 (Ran), converting it to the putatively inactive GDP-bound state.
   
 0.963
srs2
ATP-dependent DNA helicase srs2; ATP-dependent DNA helicase involved in DNA repair at least for UV-induced lesions. Also aids the recombinational repair of camptothecin-induced collapsed replication forks. Belongs to the helicase family. UvrD subfamily.
    
 
 0.959
pcn1
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.941
smc5
Structural maintenance of chromosomes protein 5; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis.
   
 0.938
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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