HSD17B6 protein (Homo sapiens) - STRING network view

STRING 9.05

HSD17B6 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	HSD17B6	hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is firs [...] (317 aa)
		(Homo sapiens)
Predicted Functional Partners:
	HSD3B1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; 3-beta-HSD is a b [...] (373 aa)	•	•	0.973
	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1; Catalyzes the formation of aromatic C18 [...] (503 aa)	•	•	0.964
	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4; Cytochromes P450 are a group of heme-thi [...] (503 aa)	•	•	0.963
	CYP1B1	cytochrome P450, family 1, subfamily B, polypeptide 1; Cytochromes P450 are a group of heme-thi [...] (543 aa)	•	•	0.963
	CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5; Cytochromes P450 are a group of heme-thi [...] (502 aa)	•	•	0.963
	CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43; Exhibits low testosterone 6-beta-hydrox [...] (504 aa)	•	•	0.963
	HSD3B2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; 3-beta-HSD is a b [...] (372 aa)	•	•	0.963
	SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1; May control the level of the estroge [...] (294 aa)	•	•	0.953
	CYP11B1	cytochrome P450, family 11, subfamily B, polypeptide 1; Has steroid 11-beta-hydroxylase activit [...] (503 aa)	•	•	0.951
	SRD5A2	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alp [...] (253 aa)	•	•	0.947

Views:

Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

required confidence (score):

interactors shown:

or custom value:

or custom limit:

additional (white) nodes

Server load: medium (47%)

Permalink