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Mr1 Mr1 B2m B2m A0A0G2K1K4_RAT A0A0G2K1K4_RAT Cd8a Cd8a RT1-Da RT1-Da Cd74 Cd74 RT1-A RT1-A RT1-S3 RT1-S3 RT1-A2 RT1-A2 RT1-DOa RT1-DOa Tmem184c Tmem184c
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
Mr1Major histocompatibility complex class I-related gene protein; Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T- cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent (By similarity). (353 aa)    
Predicted Functional Partners:
B2m
Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
   
 0.820
A0A0G2K1K4_RAT
Ig-like domain-containing protein.
    
 
 0.755
Cd8a
T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...]
    
 
 0.753
RT1-Da
Histocompatibility 2, class II antigen E alpha; Belongs to the MHC class II family.
   
 
0.643
Cd74
H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44.
   
 
 0.623
RT1-A
RT1 class Ia, locus A1; Belongs to the MHC class I family.
  
 
0.598
RT1-S3
RT1 class Ib, locus S3; Belongs to the MHC class I family.
  
 
 
0.595
RT1-A2
RT1 class I histocompatibility antigen, AA alpha chain; Involved in the presentation of foreign antigens to the immune system.
  
 
 
0.594
RT1-DOa
RT1 class II, locus DOa; Belongs to the MHC class II family.
   
 
 0.581
Tmem184c
Transmembrane protein 184C; Possible tumor suppressor which may play a role in cell growth; Belongs to the TMEM184 family.
      
 0.571
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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