node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Eea1 | Gapvd1 | ENSRNOP00000071305 | ENSRNOP00000063504 | Early endosome antigen 1. | GTPase-activating protein and VPS9 domains 1. | 0.564 |
Eea1 | Gga1 | ENSRNOP00000071305 | ENSRNOP00000059486 | Early endosome antigen 1. | Golgi-associated, gamma adaptin ear-containing, ARF-binding protein 1. | 0.473 |
Eea1 | Gga2 | ENSRNOP00000071305 | ENSRNOP00000025309 | Early endosome antigen 1. | Golgi associated, gamma adaptin ear containing, ARF binding protein 2, isoform CRA_a. | 0.439 |
Eea1 | Gga3 | ENSRNOP00000071305 | ENSRNOP00000069301 | Early endosome antigen 1. | ADP-ribosylation factor-binding protein GGA3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Involved in BACE1 transport and sorting as well as regulation of BACE1 protein levels. Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VH [...] | 0.491 |
Eea1 | Rab4a | ENSRNOP00000071305 | ENSRNOP00000048878 | Early endosome antigen 1. | Ras-related protein Rab-4A; Protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling. | 0.776 |
Eea1 | Rab5c | ENSRNOP00000071305 | ENSRNOP00000031520 | Early endosome antigen 1. | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | 0.970 |
Eea1 | Rabep1 | ENSRNOP00000071305 | ENSRNOP00000050017 | Early endosome antigen 1. | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium. | 0.940 |
Eea1 | Rabgef1 | ENSRNOP00000071305 | ENSRNOP00000001196 | Early endosome antigen 1. | RAB guanine nucleotide exchange factor (GEF) 1 (Predicted), isoform CRA_a. | 0.838 |
Eea1 | Rbsn | ENSRNOP00000071305 | ENSRNOP00000015602 | Early endosome antigen 1. | Zinc finger, FYVE domain containing 20 (Predicted). | 0.408 |
Gapvd1 | Eea1 | ENSRNOP00000063504 | ENSRNOP00000071305 | GTPase-activating protein and VPS9 domains 1. | Early endosome antigen 1. | 0.564 |
Gapvd1 | Rab5c | ENSRNOP00000063504 | ENSRNOP00000031520 | GTPase-activating protein and VPS9 domains 1. | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | 0.843 |
Gapvd1 | Rabep1 | ENSRNOP00000063504 | ENSRNOP00000050017 | GTPase-activating protein and VPS9 domains 1. | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium. | 0.789 |
Gapvd1 | Rabgef1 | ENSRNOP00000063504 | ENSRNOP00000001196 | GTPase-activating protein and VPS9 domains 1. | RAB guanine nucleotide exchange factor (GEF) 1 (Predicted), isoform CRA_a. | 0.758 |
Gapvd1 | Rbsn | ENSRNOP00000063504 | ENSRNOP00000015602 | GTPase-activating protein and VPS9 domains 1. | Zinc finger, FYVE domain containing 20 (Predicted). | 0.438 |
Gga1 | Eea1 | ENSRNOP00000059486 | ENSRNOP00000071305 | Golgi-associated, gamma adaptin ear-containing, ARF-binding protein 1. | Early endosome antigen 1. | 0.473 |
Gga1 | Gga2 | ENSRNOP00000059486 | ENSRNOP00000025309 | Golgi-associated, gamma adaptin ear-containing, ARF-binding protein 1. | Golgi associated, gamma adaptin ear containing, ARF binding protein 2, isoform CRA_a. | 0.954 |
Gga1 | Gga3 | ENSRNOP00000059486 | ENSRNOP00000069301 | Golgi-associated, gamma adaptin ear-containing, ARF-binding protein 1. | ADP-ribosylation factor-binding protein GGA3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Involved in BACE1 transport and sorting as well as regulation of BACE1 protein levels. Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VH [...] | 0.685 |
Gga1 | Rab4a | ENSRNOP00000059486 | ENSRNOP00000048878 | Golgi-associated, gamma adaptin ear-containing, ARF-binding protein 1. | Ras-related protein Rab-4A; Protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling. | 0.420 |
Gga1 | Rabep1 | ENSRNOP00000059486 | ENSRNOP00000050017 | Golgi-associated, gamma adaptin ear-containing, ARF-binding protein 1. | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium. | 0.961 |
Gga1 | Rabgef1 | ENSRNOP00000059486 | ENSRNOP00000001196 | Golgi-associated, gamma adaptin ear-containing, ARF-binding protein 1. | RAB guanine nucleotide exchange factor (GEF) 1 (Predicted), isoform CRA_a. | 0.408 |