node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD16A | SPAG7 | ENSP00000379282 | ENSP00000206020 | Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). | Sperm associated antigen 7. | 0.430 |
CD34 | FAM220A | ENSP00000310036 | ENSP00000317289 | Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. | Protein FAM220A; May negatively regulate STAT3. | 0.495 |
CD34 | SPAG7 | ENSP00000310036 | ENSP00000206020 | Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. | Sperm associated antigen 7. | 0.495 |
FAM220A | CD34 | ENSP00000317289 | ENSP00000310036 | Protein FAM220A; May negatively regulate STAT3. | Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. | 0.495 |
FAM220A | SPAG7 | ENSP00000317289 | ENSP00000206020 | Protein FAM220A; May negatively regulate STAT3. | Sperm associated antigen 7. | 0.952 |
KLHL20 | SPAG7 | ENSP00000209884 | ENSP00000206020 | Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting inte [...] | Sperm associated antigen 7. | 0.440 |
M0QYU9_HUMAN | SPAG7 | ENSP00000470086 | ENSP00000206020 | Uncharacterized protein. | Sperm associated antigen 7. | 0.447 |
RPAP3 | SNU13 | ENSP00000005386 | ENSP00000383949 | RNA polymerase II-associated protein 3; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Belongs to the RPAP3 family. | NHP2-like protein 1, N-terminally processed; Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. | 0.596 |
RPAP3 | SPAG7 | ENSP00000005386 | ENSP00000206020 | RNA polymerase II-associated protein 3; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Belongs to the RPAP3 family. | Sperm associated antigen 7. | 0.467 |
SMIM7 | SPAG7 | ENSP00000486146 | ENSP00000206020 | Small integral membrane protein 7. | Sperm associated antigen 7. | 0.455 |
SNU13 | RPAP3 | ENSP00000383949 | ENSP00000005386 | NHP2-like protein 1, N-terminally processed; Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. | RNA polymerase II-associated protein 3; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Belongs to the RPAP3 family. | 0.596 |
SNU13 | SPAG7 | ENSP00000383949 | ENSP00000206020 | NHP2-like protein 1, N-terminally processed; Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. | Sperm associated antigen 7. | 0.411 |
SPAG7 | ABHD16A | ENSP00000206020 | ENSP00000379282 | Sperm associated antigen 7. | Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase. Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). | 0.430 |
SPAG7 | CD34 | ENSP00000206020 | ENSP00000310036 | Sperm associated antigen 7. | Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. | 0.495 |
SPAG7 | FAM220A | ENSP00000206020 | ENSP00000317289 | Sperm associated antigen 7. | Protein FAM220A; May negatively regulate STAT3. | 0.952 |
SPAG7 | KLHL20 | ENSP00000206020 | ENSP00000209884 | Sperm associated antigen 7. | Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting inte [...] | 0.440 |
SPAG7 | M0QYU9_HUMAN | ENSP00000206020 | ENSP00000470086 | Sperm associated antigen 7. | Uncharacterized protein. | 0.447 |
SPAG7 | RPAP3 | ENSP00000206020 | ENSP00000005386 | Sperm associated antigen 7. | RNA polymerase II-associated protein 3; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Belongs to the RPAP3 family. | 0.467 |
SPAG7 | SMIM7 | ENSP00000206020 | ENSP00000486146 | Sperm associated antigen 7. | Small integral membrane protein 7. | 0.455 |
SPAG7 | SNU13 | ENSP00000206020 | ENSP00000383949 | Sperm associated antigen 7. | NHP2-like protein 1, N-terminally processed; Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. | 0.411 |