node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cbl1 | str2 | O94350 | O94607 | Cystathionine beta-lyase. | Siderophore iron transporter 2; Involved in the transport of siderophore iron and so has a role in iron homeostasis; Belongs to the major facilitator superfamily. | 0.455 |
ctr5 | ctr6 | Q9P7F9 | Q9USV7 | Copper transport protein ctr5; Required for high affinity copper (probably reduced Cu I) transport into the cell. | Copper transport protein ctr6; Mobilizes stored copper from the vacuole to the cytoplasm under conditions of copper limitation; Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. | 0.948 |
ctr5 | fep1 | Q9P7F9 | Q10134 | Copper transport protein ctr5; Required for high affinity copper (probably reduced Cu I) transport into the cell. | Iron-sensing transcription factor 1; Represses the expression of the iron transporter fio1 in response to high iron concentrations. Binds to the consensus sequence 5'-[AT]GATAA-3'. Also represses the expression of str1, str2 and str3. | 0.460 |
ctr5 | fio1 | Q9P7F9 | Q09920 | Copper transport protein ctr5; Required for high affinity copper (probably reduced Cu I) transport into the cell. | Iron transport multicopper oxidase fio1; Could be an iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport. | 0.802 |
ctr5 | fip1 | Q9P7F9 | Q09919 | Copper transport protein ctr5; Required for high affinity copper (probably reduced Cu I) transport into the cell. | Plasma membrane iron permease; Permease for high affinity iron uptake. Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family. | 0.591 |
ctr5 | frp1 | Q9P7F9 | Q04800 | Copper transport protein ctr5; Required for high affinity copper (probably reduced Cu I) transport into the cell. | Ferric reductase transmembrane component 1; Metalloreductase responsible for reducing extracellular iron and copper prior to import (By similarity). Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores (By similarity). Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high- affinity Fe(2+) transport complex in the plasma membrane (By similarity). Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity). | 0.555 |
ctr5 | mac1 | Q9P7F9 | Q10268 | Copper transport protein ctr5; Required for high affinity copper (probably reduced Cu I) transport into the cell. | Membrane-anchored protein 1; Required for correct cell separation at high temperatures; To yeast YOL019W and YMR063W. | 0.551 |
ctr5 | str2 | Q9P7F9 | O94607 | Copper transport protein ctr5; Required for high affinity copper (probably reduced Cu I) transport into the cell. | Siderophore iron transporter 2; Involved in the transport of siderophore iron and so has a role in iron homeostasis; Belongs to the major facilitator superfamily. | 0.435 |
ctr6 | ctr5 | Q9USV7 | Q9P7F9 | Copper transport protein ctr6; Mobilizes stored copper from the vacuole to the cytoplasm under conditions of copper limitation; Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. | Copper transport protein ctr5; Required for high affinity copper (probably reduced Cu I) transport into the cell. | 0.948 |
ctr6 | fio1 | Q9USV7 | Q09920 | Copper transport protein ctr6; Mobilizes stored copper from the vacuole to the cytoplasm under conditions of copper limitation; Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. | Iron transport multicopper oxidase fio1; Could be an iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport. | 0.631 |
ctr6 | mac1 | Q9USV7 | Q10268 | Copper transport protein ctr6; Mobilizes stored copper from the vacuole to the cytoplasm under conditions of copper limitation; Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. | Membrane-anchored protein 1; Required for correct cell separation at high temperatures; To yeast YOL019W and YMR063W. | 0.630 |
ctr6 | str2 | Q9USV7 | O94607 | Copper transport protein ctr6; Mobilizes stored copper from the vacuole to the cytoplasm under conditions of copper limitation; Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. | Siderophore iron transporter 2; Involved in the transport of siderophore iron and so has a role in iron homeostasis; Belongs to the major facilitator superfamily. | 0.505 |
fep1 | ctr5 | Q10134 | Q9P7F9 | Iron-sensing transcription factor 1; Represses the expression of the iron transporter fio1 in response to high iron concentrations. Binds to the consensus sequence 5'-[AT]GATAA-3'. Also represses the expression of str1, str2 and str3. | Copper transport protein ctr5; Required for high affinity copper (probably reduced Cu I) transport into the cell. | 0.460 |
fep1 | fio1 | Q10134 | Q09920 | Iron-sensing transcription factor 1; Represses the expression of the iron transporter fio1 in response to high iron concentrations. Binds to the consensus sequence 5'-[AT]GATAA-3'. Also represses the expression of str1, str2 and str3. | Iron transport multicopper oxidase fio1; Could be an iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport. | 0.898 |
fep1 | fip1 | Q10134 | Q09919 | Iron-sensing transcription factor 1; Represses the expression of the iron transporter fio1 in response to high iron concentrations. Binds to the consensus sequence 5'-[AT]GATAA-3'. Also represses the expression of str1, str2 and str3. | Plasma membrane iron permease; Permease for high affinity iron uptake. Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family. | 0.881 |
fep1 | frp1 | Q10134 | Q04800 | Iron-sensing transcription factor 1; Represses the expression of the iron transporter fio1 in response to high iron concentrations. Binds to the consensus sequence 5'-[AT]GATAA-3'. Also represses the expression of str1, str2 and str3. | Ferric reductase transmembrane component 1; Metalloreductase responsible for reducing extracellular iron and copper prior to import (By similarity). Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores (By similarity). Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high- affinity Fe(2+) transport complex in the plasma membrane (By similarity). Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity). | 0.813 |
fep1 | str2 | Q10134 | O94607 | Iron-sensing transcription factor 1; Represses the expression of the iron transporter fio1 in response to high iron concentrations. Binds to the consensus sequence 5'-[AT]GATAA-3'. Also represses the expression of str1, str2 and str3. | Siderophore iron transporter 2; Involved in the transport of siderophore iron and so has a role in iron homeostasis; Belongs to the major facilitator superfamily. | 0.775 |
fio1 | ctr5 | Q09920 | Q9P7F9 | Iron transport multicopper oxidase fio1; Could be an iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport. | Copper transport protein ctr5; Required for high affinity copper (probably reduced Cu I) transport into the cell. | 0.802 |
fio1 | ctr6 | Q09920 | Q9USV7 | Iron transport multicopper oxidase fio1; Could be an iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport. | Copper transport protein ctr6; Mobilizes stored copper from the vacuole to the cytoplasm under conditions of copper limitation; Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. | 0.631 |
fio1 | fep1 | Q09920 | Q10134 | Iron transport multicopper oxidase fio1; Could be an iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport. | Iron-sensing transcription factor 1; Represses the expression of the iron transporter fio1 in response to high iron concentrations. Binds to the consensus sequence 5'-[AT]GATAA-3'. Also represses the expression of str1, str2 and str3. | 0.898 |