STRINGSTRING
str2 str2 fep1 fep1 frp1 frp1 fio1 fio1 fip1 fip1 ctr6 ctr6 mac1 mac1 cbl1 cbl1 ctr5 ctr5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
str2Siderophore iron transporter 2; Involved in the transport of siderophore iron and so has a role in iron homeostasis; Belongs to the major facilitator superfamily. (597 aa)    
Predicted Functional Partners:
fep1
Iron-sensing transcription factor 1; Represses the expression of the iron transporter fio1 in response to high iron concentrations. Binds to the consensus sequence 5'-[AT]GATAA-3'. Also represses the expression of str1, str2 and str3.
   
 
 0.775
frp1
Ferric reductase transmembrane component 1; Metalloreductase responsible for reducing extracellular iron and copper prior to import (By similarity). Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores (By similarity). Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high- affinity Fe(2+) transport complex in the plasma membrane (By similarity). Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity).
   
  
 0.744
fio1
Iron transport multicopper oxidase fio1; Could be an iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport.
   
 
 0.670
fip1
Plasma membrane iron permease; Permease for high affinity iron uptake. Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
   
 
 0.651
ctr6
Copper transport protein ctr6; Mobilizes stored copper from the vacuole to the cytoplasm under conditions of copper limitation; Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
      
 0.505
mac1
Membrane-anchored protein 1; Required for correct cell separation at high temperatures; To yeast YOL019W and YMR063W.
   
 
 0.483
cbl1
Cystathionine beta-lyase.
   
  
 0.455
ctr5
Copper transport protein ctr5; Required for high affinity copper (probably reduced Cu I) transport into the cell.
   
  
 0.435
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
Server load: low (16%) [HD]