MAP4K4 protein (Homo sapiens) - STRING network view

STRING 9.05

MAP4K4 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4; Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway (1320 aa)
		(Homo sapiens)
Predicted Functional Partners:
	NCK1	NCK adaptor protein 1; Adapter protein which associates with tyrosine- phosphorylated growth fa [...] (377 aa)	•	•	•		0.986
	MAP3K1	mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduc [...] (1512 aa)	•	•	•	•	0.964
	RAP2A	RAP2A, member of RAS oncogene family (183 aa)	•		•		0.929
	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotr [...] (455 aa)		•	•		0.908
	EPHB1	EPH receptor B1; Receptor for members of the ephrin-B family. Binds to ephrin-B1, -B2 and -B3. [...] (984 aa)		•	•	•	0.907
	EPHB2	EPH receptor B2; Receptor for members of the ephrin-B family. Acts as a tumor suppressor (987 aa)		•	•	•	0.907
	EFNB1	ephrin-B1; Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the col [...] (346 aa)		•	•		0.905
	TRADD	TNFRSF1A-associated via death domain; Adapter molecule for TNFRSF1A/TNFR1 that specifically ass [...] (312 aa)		•	•		0.901
	TP53	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)		•	•		0.901
	RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1; Involved in the transduction of TNF si [...] (671 aa)		•	•	•	0.901

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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