SERPINA1 protein (Homo sapiens) - STRING network view

STRING 9.05

SERPINA1 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin (418 aa)
		(Homo sapiens)
Predicted Functional Partners:
	ELANE	elastase, neutrophil expressed; Modifies the functions of natural killer cells, monocytes and g [...] (267 aa)		•		•	0.991
	TGFB1	transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differ [...] (390 aa)			•	•	0.981
	A2M	alpha-2-macroglobulin; Is able to inhibit all four classes of proteinases by a unique 'trapping [...] (1474 aa)			•	•	0.973
	KLK3	kallikrein-related peptidase 3; Hydrolyzes semenogelin-1 thus leading to the liquefaction of th [...] (261 aa)		•		•	0.972
	MIS12	MIS12, MIND kinetochore complex component, homolog (S. pombe); Part of the MIS12 complex which [...] (205 aa)		•			0.962
	ALB	albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2 [...] (609 aa)	•		•	•	0.951
	PLG	plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a [...] (810 aa)			•	•	0.928
	FN1	fibronectin 1; Fibronectins bind cell surfaces and various compounds including collagen, fibrin [...] (2477 aa)			•	•	0.922
	TIMP1	TIMP metallopeptidase inhibitor 1; Complexes with metalloproteinases (such as collagenases) and [...] (207 aa)			•	•	0.918
	KNG1	kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an impor [...] (644 aa)			•	•	0.918

Views:

Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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