STRINGSTRING
NPPA NPPA NPR1 NPR1 NPR2 NPR2 G1TFP9_RABIT G1TFP9_RABIT NPR3 NPR3 NPPB NPPB CORIN CORIN NKX2-5 NKX2-5 GUCY2C GUCY2C GUCY2F GUCY2F GUCY2D GUCY2D
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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NPPAAtrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (153 aa)    
Predicted Functional Partners:
NPR1
Guanylate cyclase.
    
 0.998
NPR2
Guanylate cyclase.
   
 0.997
G1TFP9_RABIT
Guanylate cyclase.
    
 0.975
NPR3
Natriuretic peptide receptor 3.
    
 0.969
NPPB
Uncharacterized protein.
   
 
 0.952
CORIN
Corin, serine peptidase.
     
 0.925
NKX2-5
NK2 homeobox 5.
   
 
 0.924
GUCY2C
Guanylate cyclase.
    
 0.919
GUCY2F
Guanylate cyclase.
    
 0.917
GUCY2D
Guanylate cyclase.
    
 0.916
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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