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Prps2 Prps2 Prpsap2 Prpsap2 Prpsap1 Prpsap1 Ppat Ppat Rbks Rbks Tkt Tkt Rpia Rpia Tktl2 Tktl2 Tktl1 Tktl1 Pgm1 Pgm1 Umps Umps
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
Prps2Ribose-phosphate pyrophosphokinase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family. (318 aa)    
Predicted Functional Partners:
Prpsap2
Phosphoribosyl pyrophosphate synthase-associated protein 2; Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.
  
0.999
Prpsap1
Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.
  
0.999
Ppat
Amidophosphoribosyltransferase.
  
 0.968
Rbks
Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
  
 0.963
Tkt
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
   
 
 0.955
Rpia
Ribose 5-phosphate isomerase A (Predicted).
  
 
 0.951
Tktl2
Transketolase-like 2 (Predicted).
   
 
 0.950
Tktl1
Transketolase-like protein 1.
   
 
 0.949
Pgm1
Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose.
   
 
 0.920
Umps
Uridine monophosphate synthetase, isoform CRA_a.
  
 
 0.915
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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