node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCL11 | CSF2 | ENSBTAP00000005406 | ENSBTAP00000002054 | Eotaxin; Attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary; Belongs to the intercrine beta (chemokine CC) family. | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | 0.985 |
CCL11 | CSF3 | ENSBTAP00000005406 | ENSBTAP00000028610 | Eotaxin; Attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary; Belongs to the intercrine beta (chemokine CC) family. | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes; Belongs to the IL-6 superfamily. | 0.983 |
CCL11 | IFNG | ENSBTAP00000005406 | ENSBTAP00000016634 | Eotaxin; Attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary; Belongs to the intercrine beta (chemokine CC) family. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.948 |
CCL11 | IL1A | ENSBTAP00000005406 | ENSBTAP00000013665 | Eotaxin; Attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary; Belongs to the intercrine beta (chemokine CC) family. | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. | 0.930 |
CCL11 | IL1B | ENSBTAP00000005406 | ENSBTAP00000001745 | Eotaxin; Attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary; Belongs to the intercrine beta (chemokine CC) family. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.892 |
CCL11 | IL2 | ENSBTAP00000005406 | ENSBTAP00000027819 | Eotaxin; Attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary; Belongs to the intercrine beta (chemokine CC) family. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.857 |
CCL11 | IL3 | ENSBTAP00000005406 | ENSBTAP00000002774 | Eotaxin; Attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary; Belongs to the intercrine beta (chemokine CC) family. | Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. | 0.822 |
CCL11 | IL6 | ENSBTAP00000005406 | ENSBTAP00000019865 | Eotaxin; Attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary; Belongs to the intercrine beta (chemokine CC) family. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.837 |
CSF2 | CCL11 | ENSBTAP00000002054 | ENSBTAP00000005406 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Eotaxin; Attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary; Belongs to the intercrine beta (chemokine CC) family. | 0.985 |
CSF2 | CSF2RA-2 | ENSBTAP00000002054 | ENSBTAP00000067448 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Fibronectin type-III domain-containing protein. | 0.992 |
CSF2 | CSF2RB | ENSBTAP00000002054 | ENSBTAP00000011947 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Colony stimulating factor 2 receptor beta common subunit. | 0.994 |
CSF2 | CSF3 | ENSBTAP00000002054 | ENSBTAP00000028610 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes; Belongs to the IL-6 superfamily. | 0.991 |
CSF2 | IFNG | ENSBTAP00000002054 | ENSBTAP00000016634 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.992 |
CSF2 | IL1A | ENSBTAP00000002054 | ENSBTAP00000013665 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. | 0.989 |
CSF2 | IL1B | ENSBTAP00000002054 | ENSBTAP00000001745 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.988 |
CSF2 | IL2 | ENSBTAP00000002054 | ENSBTAP00000027819 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.984 |
CSF2 | IL3 | ENSBTAP00000002054 | ENSBTAP00000002774 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. | 0.964 |
CSF2 | IL6 | ENSBTAP00000002054 | ENSBTAP00000019865 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.971 |
CSF2RA-2 | CSF2 | ENSBTAP00000067448 | ENSBTAP00000002054 | Fibronectin type-III domain-containing protein. | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | 0.992 |
CSF2RA-2 | CSF2RB | ENSBTAP00000067448 | ENSBTAP00000011947 | Fibronectin type-III domain-containing protein. | Colony stimulating factor 2 receptor beta common subunit. | 0.995 |