node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC37 | HSP90AA1 | ENSGALP00000072245 | ENSGALP00000060285 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.918 |
CDC37 | HSP90B1 | ENSGALP00000072245 | ENSGALP00000054843 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). Has ATPase activity (By similarity). | 0.735 |
CDC37 | HSPA4 | ENSGALP00000072245 | ENSGALP00000054757 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. | Heat shock protein family A (Hsp70) member 4. | 0.435 |
CDC37 | HSPA8 | ENSGALP00000072245 | ENSGALP00000051563 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.414 |
CDC37 | MLKL | ENSGALP00000072245 | ENSGALP00000004360 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. | Mixed lineage kinase domain like pseudokinase. | 0.617 |
CDC37 | PTGES3 | ENSGALP00000072245 | ENSGALP00000069892 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. | Prostaglandin E synthase 3; Molecular chaperone. | 0.778 |
CDC37 | STIP1 | ENSGALP00000072245 | ENSGALP00000066776 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. | Stress induced phosphoprotein 1. | 0.828 |
DNAJA1 | HSP90AA1 | ENSGALP00000064370 | ENSGALP00000060285 | Uncharacterized protein. | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | 0.928 |
DNAJA1 | HSP90B1 | ENSGALP00000064370 | ENSGALP00000054843 | Uncharacterized protein. | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). Has ATPase activity (By similarity). | 0.611 |
DNAJA1 | HSPA4 | ENSGALP00000064370 | ENSGALP00000054757 | Uncharacterized protein. | Heat shock protein family A (Hsp70) member 4. | 0.713 |
DNAJA1 | HSPA8 | ENSGALP00000064370 | ENSGALP00000051563 | Uncharacterized protein. | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.963 |
DNAJA1 | PTGES3 | ENSGALP00000064370 | ENSGALP00000069892 | Uncharacterized protein. | Prostaglandin E synthase 3; Molecular chaperone. | 0.569 |
DNAJA1 | STIP1 | ENSGALP00000064370 | ENSGALP00000066776 | Uncharacterized protein. | Stress induced phosphoprotein 1. | 0.798 |
HSP90AA1 | CDC37 | ENSGALP00000060285 | ENSGALP00000072245 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. | 0.918 |
HSP90AA1 | DNAJA1 | ENSGALP00000060285 | ENSGALP00000064370 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Uncharacterized protein. | 0.928 |
HSP90AA1 | HSP90B1 | ENSGALP00000060285 | ENSGALP00000054843 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). Has ATPase activity (By similarity). | 0.937 |
HSP90AA1 | HSPA4 | ENSGALP00000060285 | ENSGALP00000054757 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Heat shock protein family A (Hsp70) member 4. | 0.923 |
HSP90AA1 | HSPA8 | ENSGALP00000060285 | ENSGALP00000051563 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.977 |
HSP90AA1 | MLKL | ENSGALP00000060285 | ENSGALP00000004360 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Mixed lineage kinase domain like pseudokinase. | 0.914 |
HSP90AA1 | PTGES3 | ENSGALP00000060285 | ENSGALP00000069892 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] | Prostaglandin E synthase 3; Molecular chaperone. | 0.961 |