Icam1 protein (Mus musculus) - STRING network view

STRING 9.05

Icam1 protein (Mus musculus) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	Icam1	intercellular adhesion molecule 1 Gene; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation (By similarity) (537 aa)
		(Mus musculus)
Predicted Functional Partners:
	Itgal	integrin alpha L Gene; Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. [...] (1201 aa)		•	•	•	0.998
	Cd44	CD44 antigen Gene; Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothe [...] (780 aa)			•	•	0.982
	Itgb2	integrin beta 2 Gene; Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. [...] (770 aa)		•	•	•	0.982
	Ezr	ezrin Gene; Probably involved in connections of major cytoskeletal structures to the plasma mem [...] (586 aa)		•	•	•	0.981
	Tnf	tumor necrosis factor Gene; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mai [...] (235 aa)				•	0.978
	Il6	interleukin 6 Gene; Cytokine with a wide variety of biological functions. It is a potent induce [...] (211 aa)	•			•	0.964
	Cd40	CD40 antigen Gene; Receptor for TNFSF5/CD40LG (289 aa)				•	0.963
	Ncam1	neural cell adhesion molecule 1 Gene; This protein is a cell adhesion molecule involved in neur [...] (1103 aa)			•	•	0.962
	Il1a	interleukin 1 alpha Gene; Produced by activated macrophages, IL-1 stimulates thymocyte prolifer [...] (270 aa)	•			•	0.954
	Irf1	interferon regulatory factor 1 Gene; Specifically binds to the upstream regulatory region of ty [...] (329 aa)	•		•	•	0.953

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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