TNFRSF1B protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
tumor necrosis factor receptor superfamily, member 1B; Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity (461 aa)
(Homo sapiens)
Predicted Functional Partners:
TNF receptor-associated factor 2; Regulates activation of NF-kappa-B and JNK and plays a centra [...] (501 aa)
TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B [...] (416 aa)
tumor necrosis factor receptor superfamily, member 1A; Receptor for TNFSF2/TNF-alpha and homotr [...] (455 aa)
TNF receptor-associated factor 3; Regulates pathways leading to the activation of NF- kappa-B a [...] (568 aa)
TNFRSF1A-associated via death domain; The nuclear form acts as a tumor suppressor by preventing [...] (312 aa)
ADAM metallopeptidase domain 17; Cleaves the membrane-bound precursor of TNF-alpha to its matur [...] (824 aa)
lymphotoxin alpha (TNF superfamily, member 1); Cytokine that in its homotrimeric form binds to [...] (205 aa)
receptor (TNFRSF)-interacting serine-threonine kinase 1; Serine-threonine kinase which transduc [...] (671 aa)
baculoviral IAP repeat containing 2; Multi-functional protein which regulates not only caspases [...] (618 aa)
baculoviral IAP repeat containing 3; Multi-functional protein which regulates not only caspases [...] (604 aa)
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