STRINGSTRING
RAG2 RAG2 RAG1 RAG1 ENSGALP00000073724 ENSGALP00000073724 CD4 CD4 CD8A-2 CD8A-2 CD8A-3 CD8A-3 FAH FAH IL7 IL7 IL4 IL4 OVAL OVAL FOXP1 FOXP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
RAG2V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (535 aa)    
Predicted Functional Partners:
RAG1
V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break b [...]
  
 0.999
ENSGALP00000073724
Reverse transcriptase domain-containing protein.
   
 
 0.895
CD4
Uncharacterized protein.
      
 0.851
CD8A-2
Ig-like domain-containing protein.
   
  
 0.849
CD8A-3
Ig-like domain-containing protein.
      
 0.847
FAH
Fumarylacetoacetase.
      
 0.845
IL7
Interleukin-7.
      
 0.715
IL4
Interleukin 4.
   
  
 0.712
OVAL
Ovalbumin; Non-inhibitory serpin. Storage protein of egg white.
   
  
 0.710
FOXP1
Forkhead box protein P1; Transcriptional repressor.
      
 0.705
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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