Arrb1 protein (Rattus norvegicus)

STRING 9.05

Arrb1 protein (Rattus norvegicus) - STRING network view

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Your Input:
	Arrb1	Beta-arrestin-1 (Arrestin beta-1); Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting [...] (418 aa)
		(Rattus norvegicus)
Predicted Functional Partners:
	F2rl2	Proteinase-activated receptor 3 Precursor (PAR-3)(Thrombin receptor-like 2)(Coagulation factor [...] (368 aa)			•	•	0.925
	F2r	Proteinase-activated receptor 1 Precursor (PAR-1)(Thrombin receptor); High affinity receptor fo [...] (404 aa)			•	•	0.923
	Src	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)(pp60c-src)(p60-Src)(c-Src) (542 aa)	•		•	•	0.919
	Mapk3	Mitogen-activated protein kinase 3 (EC 2.7.11.24)(Extracellular signal-regulated kinase 1)(ERK- [...] (380 aa)			•	•	0.914
	Cltc	Clathrin heavy chain 1 ; Clathrin is the major protein of the polyhedral coat of coated pits an [...] (1679 aa)		•	•	•	0.909
	Mapk1	Mitogen-activated protein kinase 1 (EC 2.7.11.24)(Extracellular signal-regulated kinase 2)(ERK- [...] (358 aa)			•	•	0.906
	Dnm2	Dynamin-2 (EC 3.6.5.5); Microtubule-associated force-producing protein involved in producing mi [...] (870 aa)			•	•	0.904
	Ap1b1	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 subunit beta-1)(Adaptor protein [...] (953 aa)		•	•		0.904
	Ap1s2	adaptor-related protein complex 1, sigma 2 subunit (160 aa)			•		0.899
	F2	Prothrombin Precursor (EC 3.4.21.5)(Coagulation factor II) [Contains Activation peptide fragmen [...] (617 aa)			•		0.899

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