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PML - Protein PML; Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respe [...]
[a.k.a. TRIM19, RNF71, MYL,
ffh - Signal recognition particle; Similar to GB:M82827, GB:X56058, SP:
, SP:P29591, SP:P29592, SP:P29593, SP:Q00755, and PID:182796; identified by sequence similarity; putative
[a.k.a. TC_0294, AAF39161.1, Signal recognition particle]
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SIB - Swiss Institute of Bioinformatics
CPR - NNF Center for Protein Research
EMBL - European Molecular Biology Laboratory
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