PML protein (Homo sapiens) - STRING network view

STRING 9.05

PML protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	PML	promyelocytic leukemia; Probable transcription factor. May play an important role in recruitment of ELF4 into PML nuclear bodies. Inhibits specifically the activity of the tetrameric form of PKM2. May play a role in glycolytic metabolism by modulating the activity of PKM2. Together with SATB1, involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus (882 aa)
		(Homo sapiens)
Predicted Functional Partners:
	TP53	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)	•	•	•	0.999
	DAXX	death-domain associated protein (740 aa)	•		•	0.999
	RARA	retinoic acid receptor, alpha; This is a receptor for retinoic acid. Retinoic acid has profound [...] (462 aa)	•	•	•	0.999
	SUMO1	SUMO1 pseudogene 3; Ubiquitin-like protein which can be covalently attached to target lysines a [...] (101 aa)	•		•	0.999
	SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein which can be cov [...] (95 aa)	•		•	0.997
	MDM2	Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle a [...] (497 aa)	•		•	0.997
	SP100	SP100 nuclear antigen; May play a role in the control of gene expression (885 aa)	•	•	•	0.995
	ZFYVE9	zinc finger, FYVE domain containing 9; Involved in recruiting unphosphorylated forms of SMAD2/S [...] (1425 aa)	•	•	•	0.992
	CREBBP	CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation [...] (2442 aa)	•		•	0.984
	UBC	ubiquitin C (685 aa)	•			0.984

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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