ARRB2 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
arrestin, beta 2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] (409 aa)
(Homo sapiens)
Predicted Functional Partners:
ubiquitin C (685 aa)
Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle a [...] (497 aa)
ADP-ribosylation factor 6; GTP-binding protein that functions as an allosteric activator of the [...] (175 aa)
mitogen-activated protein kinase 1; Involved in both the initiation and regulation of meiosis, [...] (360 aa)
mitogen-activated protein kinase kinase kinase 5; Component of a protein kinase signal transduc [...] (1374 aa)
dishevelled, dsh homolog 2 (Drosophila); May play a role in the signal transduction pathway med [...] (736 aa)
transforming growth factor, beta receptor III; Binds to TGF-beta. Could be involved in capturin [...] (851 aa)
adrenergic, beta-2-, receptor, surface; Beta-adrenergic receptors mediate the catecholamine- in [...] (413 aa)
mitogen-activated protein kinase kinase 4; Dual specificity kinase that activates the JUN kinas [...] (399 aa)
chemokine (C-X-C motif) receptor 4; Receptor for the C-X-C chemokine CXCL12/SDF-1. Transduces a [...] (356 aa)
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