STRINGSTRING
Stfa1 Stfa1 Stfa3 Stfa3 Stfa2 Stfa2 Klk8 Klk8 Stfa2l1 Stfa2l1 Ctsb Ctsb Cstdc4 Cstdc4 Cstdc5 Cstdc5 Csta2 Csta2 Csta3 Csta3 Cstdc6 Cstdc6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Stfa1Stefin-1; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. (97 aa)    
Predicted Functional Partners:
Stfa3
Stefin-3; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family.
  
 
0.950
Stfa2
Cystatin-A/B.
  
 
0.944
Klk8
Kallikrein-8; Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte [...]
   
 
 0.780
Stfa2l1
Stefin-2; This is an intracellular thiol proteinase inhibitor.
  
 
0.776
Ctsb
Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family.
     
 0.765
Cstdc4
Cystatin domain-containing 4; Belongs to the cystatin family.
  
 
0.757
Cstdc5
Cystatin domain-containing 5.
  
 
0.755
Csta2
Cystatin A family member 2; Belongs to the cystatin family.
  
 
0.755
Csta3
Cystatin A family member 3.
  
 
0.753
Cstdc6
Cystatin domain-containing 6.
  
 
0.750
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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