STRING 10 
  GCK protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
GCK
glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (466 aa)
(Homo sapiens)
Predicted Functional Partners:
GCKR
glucokinase (hexokinase 4) regulator; Inhibits glucokinase by forming an inactive complex with [...] (625 aa)
     0.998
INS
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (110 aa)
      0.989
PDX1
pancreatic and duodenal homeobox 1; Activates insulin, somatostatin, glucokinase, islet amyloid [...] (283 aa)
      0.981
GPI
glucose-6-phosphate isomerase; Besides it's role as a glycolytic enzyme, mammalian GPI can func [...] (569 aa)
     0.982
HNF4A
hepatocyte nuclear factor 4, alpha (474 aa)
      0.974
NEUROD1
neuronal differentiation 1 (356 aa)
      0.971
PGM1
phosphoglucomutase 1 (580 aa)
     0.959
MAP3K1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a p [...] (1512 aa)
     0.954
FOXO1
forkhead box O1; Transcription factor that is the main target of insulin signaling and regulate [...] (655 aa)
      0.954
FOXA2
forkhead box A2; Transcription factor that is involved in embryonic development, establishment [...] (463 aa)
      0.948
 
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