GCK protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

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glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (466 aa)
(Homo sapiens)
Predicted Functional Partners:
glucokinase (hexokinase 4) regulator; Inhibits glucokinase by forming an inactive complex with [...] (625 aa)
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (110 aa)
glucose-6-phosphate isomerase; Besides it's role as a glycolytic enzyme, mammalian GPI can func [...] (569 aa)
pancreatic and duodenal homeobox 1; Activates insulin, somatostatin, glucokinase, islet amyloid [...] (283 aa)
hepatocyte nuclear factor 4, alpha (474 aa)
neuronal differentiation 1 (356 aa)
phosphoglucomutase 1 (580 aa)
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a p [...] (1512 aa)
forkhead box O1; Transcription factor that is the main target of insulin signaling and regulate [...] (655 aa)
forkhead box A2; Transcription factor that is involved in embryonic development, establishment [...] (463 aa)
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