ASIP protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

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agouti signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes (132 aa)
(Homo sapiens)
Predicted Functional Partners:
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (317 aa)
attractin (1429 aa)
solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilita [...] (509 aa)
vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusio [...] (116 aa)
leucyl/cystinyl aminopeptidase; Release of an N-terminal amino acid, cleaves before cysteine, l [...] (1025 aa)
solute carrier family 24, member 5; Cation exchanger involved in pigmentation, possibly by part [...] (500 aa)
melanocortin 4 receptor; Receptor specific to the heptapeptide core common to adrenocorticotrop [...] (332 aa)
melanocortin 3 receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is me [...] (323 aa)
melanocortin 5 receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of thi [...] (325 aa)
melanocortin 2 receptor (adrenocorticotropic hormone); Receptor for ACTH. This receptor is medi [...] (297 aa)
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