STRING 9.1 
  ASIP protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
ASIP
agouti signaling protein, nonagouti homolog (mouse); Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with a [...] (132 aa)
(Homo sapiens)
Predicted Functional Partners:
MC1R
melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); Tubulin is the major c [...] (450 aa)
      0.890
MC4R
melanocortin 4 receptor; Receptor specific to the heptapeptide core common to adrenocorticotrop [...] (332 aa)
      0.822
MC3R
melanocortin 3 receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is me [...] (323 aa)
      0.813
MC5R
melanocortin 5 receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of thi [...] (325 aa)
      0.802
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone); Receptor for ACTH. This receptor is medi [...] (297 aa)
      0.781
PNMA2
paraneoplastic antigen MA2 (364 aa)
       0.692
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans); Adapter protein involved in asymmetri [...] (372 aa)
       0.692
PNMA1
paraneoplastic antigen MA1 (353 aa)
       0.692
DCAF7
DDB1 and CUL4 associated factor 7; Involved in craniofacial development. Acts upstream of the E [...] (342 aa)
       0.692
SDC3
syndecan 3; Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a [...] (442 aa)
       0.677
 
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
 
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