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HMOX2 HMOX2 BLVRA BLVRA HMOX1 HMOX1 FECH FECH BLVRB BLVRB FXN FXN CP CP HEPH HEPH COX10 COX10 HCCS HCCS POR POR
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
HMOX2Heme oxygenase 2; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. (424 aa)    
Predicted Functional Partners:
BLVRA
Biliverdin reductase A.
   
 
 0.988
HMOX1
Heme oxygenase 1.
  
  
0.969
FECH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.
    
 0.962
BLVRB
NAD(P)-bd_dom domain-containing protein.
   
 0.943
FXN
Frataxin.
     
 0.929
CP
Ceruloplasmin; Belongs to the multicopper oxidase family.
   
 0.923
HEPH
Hephaestin; Belongs to the multicopper oxidase family.
    
 0.915
COX10
Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family.
     
 0.909
HCCS
Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.
   
 
 0.908
POR
NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the N-terminal section; belongs to the flavodoxin family.
    
 
 0.783
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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