node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GATA4 | HAND2 | ENSGALP00000030912 | ENSGALP00000045960 | Transcription factor GATA-4; Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). | Heart- and neural crest derivatives-expressed protein 2; Essential for cardiac morphogenesis. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Plays an important role in limb development, particularly in the establishment of anterior-posterior polarization of the limb bud. | 0.924 |
GATA4 | ISL1 | ENSGALP00000030912 | ENSGALP00000043151 | Transcription factor GATA-4; Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). | Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] | 0.869 |
GATA4 | MEF2C | ENSGALP00000030912 | ENSGALP00000051990 | Transcription factor GATA-4; Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). | Myocyte enhancer factor 2C. | 0.928 |
GATA4 | NKX2-5 | ENSGALP00000030912 | ENSGALP00000004542 | Transcription factor GATA-4; Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). | Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter. Belongs to the NK-2 homeobox family. | 0.995 |
GATA4 | RHOA | ENSGALP00000030912 | ENSGALP00000033584 | Transcription factor GATA-4; Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). | GTP-binding protein. | 0.923 |
GATA4 | SQSTM1 | ENSGALP00000030912 | ENSGALP00000053754 | Transcription factor GATA-4; Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). | Sequestosome 1. | 0.909 |
GATA4 | SRF | ENSGALP00000030912 | ENSGALP00000054596 | Transcription factor GATA-4; Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). | Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. | 0.835 |
GATA4 | TBX20 | ENSGALP00000030912 | ENSGALP00000052363 | Transcription factor GATA-4; Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). | T-box transcription factor TBX20; Acts as a transcriptional regulator involved in heart developmental processes. | 0.878 |
GATA4 | TBX5 | ENSGALP00000030912 | ENSGALP00000013419 | Transcription factor GATA-4; Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). | T-box transcription factor TBX5; DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. May bind to the core DNA motif of promoters. | 0.976 |
GATA4 | ZFPM2 | ENSGALP00000030912 | ENSGALP00000056149 | Transcription factor GATA-4; Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). | Zinc finger protein, FOG family member 2. | 0.822 |
HAND2 | GATA4 | ENSGALP00000045960 | ENSGALP00000030912 | Heart- and neural crest derivatives-expressed protein 2; Essential for cardiac morphogenesis. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Plays an important role in limb development, particularly in the establishment of anterior-posterior polarization of the limb bud. | Transcription factor GATA-4; Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). | 0.924 |
HAND2 | ISL1 | ENSGALP00000045960 | ENSGALP00000043151 | Heart- and neural crest derivatives-expressed protein 2; Essential for cardiac morphogenesis. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Plays an important role in limb development, particularly in the establishment of anterior-posterior polarization of the limb bud. | Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] | 0.740 |
HAND2 | MEF2C | ENSGALP00000045960 | ENSGALP00000051990 | Heart- and neural crest derivatives-expressed protein 2; Essential for cardiac morphogenesis. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Plays an important role in limb development, particularly in the establishment of anterior-posterior polarization of the limb bud. | Myocyte enhancer factor 2C. | 0.796 |
HAND2 | NKX2-5 | ENSGALP00000045960 | ENSGALP00000004542 | Heart- and neural crest derivatives-expressed protein 2; Essential for cardiac morphogenesis. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Plays an important role in limb development, particularly in the establishment of anterior-posterior polarization of the limb bud. | Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter. Belongs to the NK-2 homeobox family. | 0.948 |
HAND2 | SRF | ENSGALP00000045960 | ENSGALP00000054596 | Heart- and neural crest derivatives-expressed protein 2; Essential for cardiac morphogenesis. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Plays an important role in limb development, particularly in the establishment of anterior-posterior polarization of the limb bud. | Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. | 0.446 |
HAND2 | TBX20 | ENSGALP00000045960 | ENSGALP00000052363 | Heart- and neural crest derivatives-expressed protein 2; Essential for cardiac morphogenesis. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Plays an important role in limb development, particularly in the establishment of anterior-posterior polarization of the limb bud. | T-box transcription factor TBX20; Acts as a transcriptional regulator involved in heart developmental processes. | 0.837 |
HAND2 | TBX5 | ENSGALP00000045960 | ENSGALP00000013419 | Heart- and neural crest derivatives-expressed protein 2; Essential for cardiac morphogenesis. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Plays an important role in limb development, particularly in the establishment of anterior-posterior polarization of the limb bud. | T-box transcription factor TBX5; DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. May bind to the core DNA motif of promoters. | 0.881 |
HAND2 | ZFPM2 | ENSGALP00000045960 | ENSGALP00000056149 | Heart- and neural crest derivatives-expressed protein 2; Essential for cardiac morphogenesis. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Plays an important role in limb development, particularly in the establishment of anterior-posterior polarization of the limb bud. | Zinc finger protein, FOG family member 2. | 0.547 |
ISL1 | GATA4 | ENSGALP00000043151 | ENSGALP00000030912 | Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] | Transcription factor GATA-4; Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). | 0.869 |
ISL1 | HAND2 | ENSGALP00000043151 | ENSGALP00000045960 | Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] | Heart- and neural crest derivatives-expressed protein 2; Essential for cardiac morphogenesis. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Plays an important role in limb development, particularly in the establishment of anterior-posterior polarization of the limb bud. | 0.740 |