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USP5 - Ubiquitin carboxyl-terminal hydrolase 5; Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition; Ubiquitin specific peptidases
[a.k.a. ISOT, Hs.631661, 2DAK,
TA21275 - Ubiquitinyl hydrolase 1; SMART ZnF_UBP (SM0290) at aa 188-249, E()=1.31e-13; pfam:UCH-1 (unknown) at aa 321-352, E()=6.90e-06; pfam:UCH-2 (unknown) at aa 650-708, E()=8.80e-16
[a.k.a. XP_954414.1, InterPro:IPR001394, XP_954414,
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SIB - Swiss Institute of Bioinformatics
CPR - NNF Center for Protein Research
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