STRING 10 
  ARRB1 protein (Homo sapiens) - STRING network view
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
ARRB1
arrestin, beta 1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and re [...] (418 aa)
(Homo sapiens)
Predicted Functional Partners:
MDM2
Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (497 aa)
      0.997
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosin [...] (536 aa)
     0.991
ADRBK1
adrenergic, beta, receptor kinase 1; Specifically phosphorylates the agonist-occupied form of t [...] (689 aa)
     0.988
ARF6
ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking; regulates endoc [...] (175 aa)
     0.986
MAPK3
mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential componen [...] (379 aa)
     0.985
MAPK1
mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential componen [...] (360 aa)
     0.985
ARRB2
arrestin, beta 2 (409 aa)
    0.982
UBC
ubiquitin C (685 aa)
     0.980
MAPK10
mitogen-activated protein kinase 10; Serine/threonine-protein kinase involved in various proces [...] (464 aa)
      0.980
ADRB2
adrenoceptor beta 2, surface (413 aa)
     0.978
 
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Co-expression Experiments Databases Textmining
 
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