PGF protein (Homo sapiens) - STRING network view

STRING 9.05

PGF protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	PGF	placental growth factor; Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. It binds to receptor VEGFR-1/FLT1. PLGF-2 binds neuropilin-1 and 2 in a heparin-dependent manner (170 aa)
		(Homo sapiens)
Predicted Functional Partners:
	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor [...] (1338 aa)	•	•	•		0.999
	NRP1	neuropilin 1; The membrane-bound isoform 1 is a receptor involved in the development of the car [...] (923 aa)	•		•		0.988
	KDR	kinase insert domain receptor (a type III receptor tyrosine kinase); Receptor for VEGF or VEGFC [...] (1356 aa)		•	•		0.954
	FLT4	fms-related tyrosine kinase 4; Receptor for VEGFC. Has a tyrosine-protein kinase activity (1363 aa)		•	•		0.946
	VEGFA	vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and [...] (412 aa)	•		•	•	0.943
	PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide; Phosphorylates PtdIns, PtdIns4P and Pt [...] (1068 aa)		•	•		0.913
	PLCG1	phospholipase C, gamma 1; PLC-gamma is a major substrate for heparin-binding growth factor 1 (a [...] (1291 aa)		•	•		0.900
	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha); Binds to activated (phosphorylated) pr [...] (724 aa)		•			0.899
	AKT1	v-akt murine thymoma viral oncogene homolog 1; General protein kinase capable of phosphorylatin [...] (480 aa)			•		0.885
	IL6	interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is [...] (212 aa)			•		0.884

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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