CCL8 protein (Sus scrofa) - STRING interaction network

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Score

CCL8

C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin. (99 aa)

Predicted Functional Partners:

CCR5

0.988

CCL2

0.980

CCR2

0.977

CCR1

0.976

CCL27

0.962

ACKR4

0.936

CXCL10

0.922

CCR8

0.892

CXCR4

0.851

CXCR3

0.850

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACKR4	CCL8	ENSSSCP00000012393	ENSSSCP00000032773	Chemokine (C-C motif) receptor-like protein 1; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin.	0.936
CCL2	CCL27	ENSSSCP00000018779	ENSSSCP00000011696	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine 27.	0.953
CCL2	CCL8	ENSSSCP00000018779	ENSSSCP00000032773	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin.	0.980
CCL2	CCR1	ENSSSCP00000018779	ENSSSCP00000012073	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.943
CCL2	CCR2	ENSSSCP00000018779	ENSSSCP00000024949	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family.	0.999
CCL2	CCR5	ENSSSCP00000018779	ENSSSCP00000072998	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family.	0.956
CCL2	CCR8	ENSSSCP00000018779	ENSSSCP00000024418	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family.	0.859
CCL2	CXCL10	ENSSSCP00000018779	ENSSSCP00000032297	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-X-C motif chemokine.	0.943
CCL2	CXCR3	ENSSSCP00000018779	ENSSSCP00000029108	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-X-C chemokine receptor type 3 isoform 1; Belongs to the G-protein coupled receptor 1 family.	0.945
CCL2	CXCR4	ENSSSCP00000018779	ENSSSCP00000058444	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	0.966
CCL27	CCL2	ENSSSCP00000011696	ENSSSCP00000018779	C-C motif chemokine 27.	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	0.953
CCL27	CCL8	ENSSSCP00000011696	ENSSSCP00000032773	C-C motif chemokine 27.	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin.	0.962
CCL27	CCR1	ENSSSCP00000011696	ENSSSCP00000012073	C-C motif chemokine 27.	Chemokine (C-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.754
CCL27	CCR2	ENSSSCP00000011696	ENSSSCP00000024949	C-C motif chemokine 27.	C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family.	0.954
CCL27	CCR5	ENSSSCP00000011696	ENSSSCP00000072998	C-C motif chemokine 27.	C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family.	0.714
CCL27	CCR8	ENSSSCP00000011696	ENSSSCP00000024418	C-C motif chemokine 27.	C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family.	0.757
CCL27	CXCL10	ENSSSCP00000011696	ENSSSCP00000032297	C-C motif chemokine 27.	C-X-C motif chemokine.	0.831
CCL27	CXCR3	ENSSSCP00000011696	ENSSSCP00000029108	C-C motif chemokine 27.	C-X-C chemokine receptor type 3 isoform 1; Belongs to the G-protein coupled receptor 1 family.	0.785
CCL27	CXCR4	ENSSSCP00000011696	ENSSSCP00000058444	C-C motif chemokine 27.	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	0.729
CCL8	ACKR4	ENSSSCP00000032773	ENSSSCP00000012393	C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin.	Chemokine (C-C motif) receptor-like protein 1; Belongs to the G-protein coupled receptor 1 family.	0.936