T05H10.6 protein (Caenorhabditis elegans) - STRING interaction network

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	T05H10.6	T05H10.6 encodes an ortholog of the human gene PYRUVATE DEHYDROGENASE (LIPOAMIDE) ALPHA 1 (PDHA1. OMIM-312170), which when mutated leads to Leigh syndrome (OMIM-256000). the T05H10.6 protein is predicted to be mitochondrial with 68% accuracy; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components- pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (414 aa)
		(Caenorhabditis elegans)
Predicted Functional Partners:
	C04C3.3	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor (EC 1.2.4.1); The pyr [...] (352 aa)	•	•	•	•	•	•	•	0.999
	F23B12.5	F23B12.5 is orthologous to the human gene DIHYDROLIPOAMIDE DEHYDROGENASE (DLD. OMIM-109720), wh [...] (507 aa)	•		•	•	•	•	•	0.999
	LLC1.3	LLC1.3 is orthologous to the human gene DIHYDROLIPOAMIDE DEHYDROGENASE (DLD. OMIM-246900), whic [...] (495 aa)	•			•		•	•	0.997
	C30H6.7	C30H6.7 (337 aa)	•		•	•	•	•	•	0.991
	tag-173	tag-173/F27D4.5 is orthologous to the human gene BRANCHED CHAIN KETO ACID DEHYDROGENASE E1, ALP [...] (366 aa)	•	•	•		•	•	•	0.987
	ZK669.4	ZK669.4 is orthologous to the human gene DIHYDROLIPOAMIDE BRANCHED CHAIN TRANSACYLASE (E2 COMPO [...] (448 aa)	•					•	•	0.977
	ldh-1	ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB. OMIM-150100), which when [...] (333 aa)						•	•	0.955
	ZK593.1	ZK593.1 (515 aa)						•		0.941
	F25H5.3	F25H5.3a (600 aa)						•		0.935
	pyc-1	pyc-1 encodes the C. elegans pyruvate carboxylase ortholog (OMIM-266150, deficiencies in humans [...] (1175 aa)						•	•	0.918

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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