PDX1 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
pancreatic and duodenal homeobox 1; Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell (283 aa)
(Homo sapiens)
Predicted Functional Partners:
HNF1 homeobox A; Required for the expression of several liver specific genes. Binds to the inve [...] (631 aa)
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (200 aa)
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian); Acts as a transcriptional fac [...] (353 aa)
activating transcription factor 3; This protein binds the cAMP response element (CRE) (consensu [...] (181 aa)
glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity [...] (180 aa)
somatostatin; Somatostatin inhibits the release of somatotropin (116 aa)
one cut homeobox 1; Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' [...] (465 aa)
forkhead box A2; Transcription activator for a number of liver genes such as AFP, albumin, tyro [...] (463 aa)
neurogenic differentiation 1; Differentiation factor required for dendrite morphogenesis and ma [...] (356 aa)
forkhead box O1; Transcription factor (655 aa)
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network


Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (12%)