PDX1 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
pancreatic and duodenal homeobox 1; Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1-PBX1b-MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, [...] (283 aa)
(Homo sapiens)
Predicted Functional Partners:
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (110 aa)
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian); Acts as a transcriptional fac [...] (353 aa)
forkhead box A2; Transcription factor that is involved in embryonic development, establishment [...] (463 aa)
neuronal differentiation 1 (356 aa)
one cut homeobox 1; Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' [...] (465 aa)
forkhead box O1; Transcription factor that is the main target of insulin signaling and regulate [...] (655 aa)
fibroblast growth factor 10; Plays an important role in the regulation of embryonic development [...] (208 aa)
islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glyc [...] (89 aa)
glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-ce [...] (466 aa)
HNF1 homeobox A; Transcriptional activator that regulates the tissue specific expression of mul [...] (631 aa)
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