STRINGSTRING
LIMK2 LIMK2 CFL2 CFL2 ROCK1 ROCK1 ROCK2 ROCK2 PAK1 PAK1 PAK4 PAK4 PAK3 PAK3 PAK2 PAK2 PAK5 PAK5 PAK6 PAK6 LIMK1 LIMK1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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LIMK2LIM domain kinase 2; Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis by mediating phosphorylation of TPPP. (642 aa)    
Predicted Functional Partners:
CFL2
Cofilin-2; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods; Belongs to the actin-binding proteins ADF family.
   
 0.998
ROCK1
Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
   
0.949
ROCK2
Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
    
0.940
PAK1
Non-specific serine/threonine protein kinase.
    
0.931
PAK4
Non-specific serine/threonine protein kinase.
    
0.931
PAK3
Non-specific serine/threonine protein kinase.
    
0.919
PAK2
Non-specific serine/threonine protein kinase.
    
0.913
PAK5
Non-specific serine/threonine protein kinase.
    
0.913
PAK6
Protein kinase domain-containing protein.
    
 0.909
LIMK1
LIM domain kinase 1; Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Required for motility of the axon growth cone.
  
  
0.905
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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