node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACACA | PRKAA1 | ENSBTAP00000074493 | ENSBTAP00000000017 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | Non-specific serine/threonine protein kinase. | 0.950 |
ACACA | PRKAA2 | ENSBTAP00000074493 | ENSBTAP00000024965 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | Non-specific serine/threonine protein kinase. | 0.950 |
ACACA | PRKAB1 | ENSBTAP00000074493 | ENSBTAP00000007798 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | 5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] | 0.951 |
ACACA | PRKAB2 | ENSBTAP00000074493 | ENSBTAP00000073361 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | Protein kinase AMP-activated non-catalytic subunit beta 2. | 0.924 |
ACACA | PRKAG1 | ENSBTAP00000074493 | ENSBTAP00000057078 | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | 5'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] | 0.941 |
CAMKK2 | PRKAA1 | ENSBTAP00000065175 | ENSBTAP00000000017 | Calcium/calmodulin-dependent protein kinase kinase 2, beta. | Non-specific serine/threonine protein kinase. | 0.943 |
CAMKK2 | PRKAA2 | ENSBTAP00000065175 | ENSBTAP00000024965 | Calcium/calmodulin-dependent protein kinase kinase 2, beta. | Non-specific serine/threonine protein kinase. | 0.939 |
CAMKK2 | PRKAB1 | ENSBTAP00000065175 | ENSBTAP00000007798 | Calcium/calmodulin-dependent protein kinase kinase 2, beta. | 5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] | 0.942 |
CAMKK2 | PRKAB2 | ENSBTAP00000065175 | ENSBTAP00000073361 | Calcium/calmodulin-dependent protein kinase kinase 2, beta. | Protein kinase AMP-activated non-catalytic subunit beta 2. | 0.942 |
CAMKK2 | PRKAG1 | ENSBTAP00000065175 | ENSBTAP00000057078 | Calcium/calmodulin-dependent protein kinase kinase 2, beta. | 5'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] | 0.955 |
CAMKK2 | STK11 | ENSBTAP00000065175 | ENSBTAP00000015459 | Calcium/calmodulin-dependent protein kinase kinase 2, beta. | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. | 0.937 |
MTOR | PRKAA1 | ENSBTAP00000020386 | ENSBTAP00000000017 | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | Non-specific serine/threonine protein kinase. | 0.949 |
MTOR | PRKAA2 | ENSBTAP00000020386 | ENSBTAP00000024965 | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | Non-specific serine/threonine protein kinase. | 0.926 |
MTOR | PRKAB1 | ENSBTAP00000020386 | ENSBTAP00000007798 | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] | 0.920 |
MTOR | PRKAB2 | ENSBTAP00000020386 | ENSBTAP00000073361 | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | Protein kinase AMP-activated non-catalytic subunit beta 2. | 0.920 |
MTOR | PRKAG1 | ENSBTAP00000020386 | ENSBTAP00000057078 | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 5'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] | 0.924 |
MTOR | STK11 | ENSBTAP00000020386 | ENSBTAP00000015459 | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. | 0.462 |
MTOR | TSC1 | ENSBTAP00000020386 | ENSBTAP00000006842 | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | TSC complex subunit 1. | 0.911 |
MTOR | TSC2 | ENSBTAP00000020386 | ENSBTAP00000046373 | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | TSC complex subunit 2. | 0.946 |
PRKAA1 | ACACA | ENSBTAP00000000017 | ENSBTAP00000074493 | Non-specific serine/threonine protein kinase. | Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP- dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. | 0.950 |