Akr1c6 protein (Mus musculus) - STRING network view

STRING 9.05

Akr1c6 protein (Mus musculus) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	Akr1c6	aldo-keto reductase family 1, member C6 Gene; Active toward androgens, estrogens, and xenobiotic substrates. Also exhibits low 20 alpha-HSD activity. Shows a- stereospecificity in hydrogen transfer between cofactors and substrates (A-specific). Preferentially catalyzes the reduction of 4-androstenedione, 5-alpha-androstane-3,17-dione, androsterone and dehydroepiandrosterone to testosterone, dihydrotestosterone, 5- alpha-androstane-3-alpha,17-beta-diol and 5-androstene-3-beta,17- beta-diol, respectively (323 aa)
		(Mus musculus)
Predicted Functional Partners:
	Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 Gene; Most important [...] (465 aa)		•				0.944
	Akr1d1	aldo-keto reductase family 1, member D1 Gene; Efficiently catalyzes the reduction of progestero [...] (325 aa)	•	•	•	•	•	0.939
	Slco1b2	solute carrier organic anion transporter family, member 1b2 Gene; Mediates the Na(+)-independen [...] (689 aa)		•				0.933
	Mug1	murinoglobulin 1 Gene; A proteinase activates the inhibitor by specific proteolysis in the bait [...] (1476 aa)		•				0.915
	Apoh	apolipoprotein H Gene; Binds to various kinds of negatively charged substances such as heparin, [...] (345 aa)		•				0.879
	Slc27a5	solute carrier family 27 (fatty acid transporter), member 5 Gene; Acyl-CoA synthetase involved [...] (689 aa)		•		•		0.865
	Rdh7	retinol dehydrogenase 7 Gene; Acts on androgens and retinols, i.e. has steroid 3- alpha- and 17 [...] (316 aa)		•				0.861
	Ambp	alpha 1 microglobulin/bikunin Gene; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, an [...] (349 aa)		•				0.855
	Cyp2j5	cytochrome P450, family 2, subfamily j, polypeptide 5 Gene (501 aa)		•				0.853
	Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26 Gene; Cytochromes P450 are a group of he [...] (500 aa)		•		•		0.852

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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