CCL8 protein (Homo sapiens) - STRING network view

STRING 9.05

CCL8 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	CCL8	chemokine (C-C motif) ligand 8; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8 (99 aa)
		(Homo sapiens)
Predicted Functional Partners:
	CCR5	chemokine (C-C motif) receptor 5; Receptor for a number of inflammatory CC-chemokines including [...] (352 aa)	•	•	•	•	0.997
	CCR2	chemokine (C-C motif) receptor 2; Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduce [...] (374 aa)		•	•	•	0.988
	CCR1	chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP- [...] (355 aa)	•	•	•	•	0.970
	CCR3	chemokine (C-C motif) receptor 3; Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin- [...] (355 aa)		•	•	•	0.966
	XCR1	chemokine (C motif) receptor 1; Receptor for chemokines SCYC1 and SCYC2. Subsequently transduce [...] (333 aa)			•	•	0.930
	CXCR3	chemokine (C-X-C motif) receptor 3; Receptor for CXCL9, CXCL10 and CXCL11 and mediates the prol [...] (415 aa)			•	•	0.896
	CCRL1	chemokine (C-C motif) receptor-like 1; Receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25 (350 aa)	•	•		•	0.894
	CXCR4	chemokine (C-X-C motif) receptor 4; Receptor for the C-X-C chemokine CXCL12/SDF-1. Transduces a [...] (356 aa)			•	•	0.893
	CCR8	chemokine (C-C motif) receptor 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate mon [...] (355 aa)			•	•	0.886
	CXCR2	chemokine (C-X-C motif) receptor 2; Receptor for interleukin-8 which is a powerful neutrophil c [...] (360 aa)			•	•	0.884

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Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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