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MDH1 MDH1 FUM1 FUM1 MLS MLS NAD-ME2 NAD-ME2 NAD-ME1 NAD-ME1 CSY4 CSY4 CSY2 CSY2 CSY3 CSY3 FUM2 FUM2 CSY1 CSY1 CSY5 CSY5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MDH1Malate dehydrogenase 1, cytoplasmic; Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments. (332 aa)    
Predicted Functional Partners:
FUM1
Fumarate hydratase 1, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH (By similarity).
  
 0.989
MLS
Malate synthase; Does not seem to be essential for lipid utilization and gluconeogenesis in seedlings; Belongs to the malate synthase family.
   
 0.986
NAD-ME2
NAD-dependent malic enzyme 2, mitochondrial; Involved in the regulation of sugars and amino acids metabolisms during the night period.
  
 
 0.985
NAD-ME1
NAD-dependent malic enzyme 1, mitochondrial; Involved in the regulation of sugars and amino acids metabolisms during the night period.
  
 
 0.984
CSY4
Citrate synthase 4, mitochondrial; Belongs to the citrate synthase family.
  
 0.980
CSY2
Citrate synthase 2, peroxisomal; Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria.
  
 0.979
CSY3
Citrate synthase 3, peroxisomal; Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria.
  
 0.979
FUM2
Fumarate hydratase 2; Cytosolic fumarate hydratase that catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Catalyzes the dehydration of L-malate to fumarate in the cytosol: required for the massive fumarate accumulation during the day in plants grown under high nitrogen. Also required for acclimation of photosynthesis to cold: acts by mediating accumulation of fumarate at low temperature, leading to reduce accumulation of phosphorylated sugars.
  
 0.978
CSY1
Citrate synthase 1, peroxisomal; Belongs to the citrate synthase family.
  
 0.978
CSY5
Citrate synthase 5, mitochondrial; Belongs to the citrate synthase family.
  
 0.976
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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