node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Afmid | Khk | ENSMUSP00000073102 | ENSMUSP00000031053 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. | 0.595 |
Afmid | Pemt | ENSMUSP00000073102 | ENSMUSP00000099754 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. | 0.587 |
Aldoa | Aldob | ENSMUSP00000084846 | ENSMUSP00000029987 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | Fructose-bisphosphate aldolase B. | 0.780 |
Aldoa | Aldoc | ENSMUSP00000084846 | ENSMUSP00000017534 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. | 0.789 |
Aldoa | Gck | ENSMUSP00000084846 | ENSMUSP00000099984 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | Hexokinase-4; Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues. Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change it [...] | 0.863 |
Aldoa | Khk | ENSMUSP00000084846 | ENSMUSP00000031053 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. | 0.610 |
Aldoa | Tkfc | ENSMUSP00000084846 | ENSMUSP00000157520 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | ATP-dependent dihydroxyacetone kinase; Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1- mediated cellular antiviral response. | 0.907 |
Aldob | Aldoa | ENSMUSP00000029987 | ENSMUSP00000084846 | Fructose-bisphosphate aldolase B. | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | 0.780 |
Aldob | Aldoc | ENSMUSP00000029987 | ENSMUSP00000017534 | Fructose-bisphosphate aldolase B. | Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. | 0.700 |
Aldob | Gck | ENSMUSP00000029987 | ENSMUSP00000099984 | Fructose-bisphosphate aldolase B. | Hexokinase-4; Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues. Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change it [...] | 0.898 |
Aldob | Khk | ENSMUSP00000029987 | ENSMUSP00000031053 | Fructose-bisphosphate aldolase B. | Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. | 0.858 |
Aldob | Slc2a2 | ENSMUSP00000029987 | ENSMUSP00000029240 | Fructose-bisphosphate aldolase B. | Solute carrier family 2, facilitated glucose transporter member 2; Facilitative hexose transporter that mediates the transport of glucose and fructose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate. | 0.712 |
Aldob | Slc2a5 | ENSMUSP00000029987 | ENSMUSP00000030826 | Fructose-bisphosphate aldolase B. | Solute carrier family 2, facilitated glucose transporter member 5; Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency (By similarity). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake. | 0.554 |
Aldob | Tkfc | ENSMUSP00000029987 | ENSMUSP00000157520 | Fructose-bisphosphate aldolase B. | ATP-dependent dihydroxyacetone kinase; Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1- mediated cellular antiviral response. | 0.959 |
Aldoc | Aldoa | ENSMUSP00000017534 | ENSMUSP00000084846 | Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | 0.789 |
Aldoc | Aldob | ENSMUSP00000017534 | ENSMUSP00000029987 | Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. | Fructose-bisphosphate aldolase B. | 0.700 |
Aldoc | Gck | ENSMUSP00000017534 | ENSMUSP00000099984 | Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. | Hexokinase-4; Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues. Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change it [...] | 0.845 |
Aldoc | Khk | ENSMUSP00000017534 | ENSMUSP00000031053 | Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. | Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. | 0.663 |
Aldoc | Tkfc | ENSMUSP00000017534 | ENSMUSP00000157520 | Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. | ATP-dependent dihydroxyacetone kinase; Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1- mediated cellular antiviral response. | 0.917 |
Gck | Aldoa | ENSMUSP00000099984 | ENSMUSP00000084846 | Hexokinase-4; Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues. Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change it [...] | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family. | 0.863 |