node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ahsg | Anxa4 | ENSMUSP00000023583 | ENSMUSP00000109305 | Alpha-2-HS-glycoprotein; Probably involved in differentiation; Belongs to the fetuin family. | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | 0.562 |
Ahsg | Apoa1 | ENSMUSP00000023583 | ENSMUSP00000034588 | Alpha-2-HS-glycoprotein; Probably involved in differentiation; Belongs to the fetuin family. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | 0.851 |
Ahsg | Apoa4 | ENSMUSP00000023583 | ENSMUSP00000034585 | Alpha-2-HS-glycoprotein; Probably involved in differentiation; Belongs to the fetuin family. | Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons; Belongs to the apolipoprotein A1/A4/E family. | 0.782 |
Ahsg | Apoe | ENSMUSP00000023583 | ENSMUSP00000133302 | Alpha-2-HS-glycoprotein; Probably involved in differentiation; Belongs to the fetuin family. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.480 |
Ahsg | Clu | ENSMUSP00000023583 | ENSMUSP00000022616 | Alpha-2-HS-glycoprotein; Probably involved in differentiation; Belongs to the fetuin family. | Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins (By similarity). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and [...] | 0.440 |
Anxa4 | Ahsg | ENSMUSP00000109305 | ENSMUSP00000023583 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Alpha-2-HS-glycoprotein; Probably involved in differentiation; Belongs to the fetuin family. | 0.562 |
Anxa4 | Apoa1 | ENSMUSP00000109305 | ENSMUSP00000034588 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | 0.688 |
Anxa4 | Apoa4 | ENSMUSP00000109305 | ENSMUSP00000034585 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons; Belongs to the apolipoprotein A1/A4/E family. | 0.609 |
Anxa4 | Apod | ENSMUSP00000109305 | ENSMUSP00000119827 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts; Belongs to the calycin superfamily. Lipocalin family. | 0.533 |
Anxa4 | Apoe | ENSMUSP00000109305 | ENSMUSP00000133302 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.622 |
Anxa4 | Capg | ENSMUSP00000109305 | ENSMUSP00000109705 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Macrophage-capping protein; Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. Uncapping occurs either when Ca(2+) falls or when the concentration of polyphosphoinositide rises, both at low and high Ca(2+); Belongs to the villin/gelsolin family. | 0.575 |
Anxa4 | Cd68 | ENSMUSP00000109305 | ENSMUSP00000018918 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Macrosialin; Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells; Belongs to the LAMP family. | 0.489 |
Anxa4 | Clu | ENSMUSP00000109305 | ENSMUSP00000022616 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins (By similarity). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and [...] | 0.557 |
Anxa4 | S100a4 | ENSMUSP00000109305 | ENSMUSP00000001046 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Protein S100-A4; Belongs to the S-100 family. | 0.489 |
Anxa4 | S100a6 | ENSMUSP00000109305 | ENSMUSP00000001051 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity); Belongs to the S-100 family. | 0.608 |
Apoa1 | Ahsg | ENSMUSP00000034588 | ENSMUSP00000023583 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Alpha-2-HS-glycoprotein; Probably involved in differentiation; Belongs to the fetuin family. | 0.851 |
Apoa1 | Anxa4 | ENSMUSP00000034588 | ENSMUSP00000109305 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. | 0.688 |
Apoa1 | Apoa4 | ENSMUSP00000034588 | ENSMUSP00000034585 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons; Belongs to the apolipoprotein A1/A4/E family. | 0.971 |
Apoa1 | Apod | ENSMUSP00000034588 | ENSMUSP00000119827 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts; Belongs to the calycin superfamily. Lipocalin family. | 0.929 |
Apoa1 | Apoe | ENSMUSP00000034588 | ENSMUSP00000133302 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.999 |