SFRP1 protein (Homo sapiens) - STRING interaction network

SFRP1 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	SFRP1	Secreted frizzled-related protein 1 precursor (sFRP-1) (Frizzled- related protein 1) (FRP-1) (Secreted apoptosis-related protein 2) (SARP-2); Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry in [...] (314 aa)
		(Homo sapiens)
Predicted Functional Partners:
	WNT1	Proto-oncogene protein Wnt-1 precursor; Ligand for members of the frizzled family of seven tran [...] (370 aa)	•	•	•	0.998
	WNT5A	Protein Wnt-5a precursor; Ligand for members of the frizzled family of seven transmembrane rece [...] (380 aa)		•	•	0.990
	WNT3A	Protein Wnt-3a precursor; Ligand for members of the frizzled family of seven transmembrane rece [...] (385 aa)		•	•	0.990
	WNT2	Protein Wnt-2 precursor (IRP protein) (Int-1-related protein); Ligand for members of the frizzl [...] (360 aa)	•	•	•	0.980
	WNT7B	Protein Wnt-7b precursor; Ligand for members of the frizzled family of seven transmembrane rece [...] (349 aa)		•	•	0.979
	WNT4	Protein Wnt-4 precursor; Ligand for members of the frizzled family of seven transmembrane recep [...] (351 aa)	•	•	•	0.973
	WNT2B	Protein Wnt-2b precursor (Wnt-13); Ligand for members of the frizzled family of seven transmemb [...] (391 aa)		•	•	0.960
	WNT6	Protein Wnt-6 precursor; Ligand for members of the frizzled family of seven transmembrane recep [...] (365 aa)		•	•	0.953
	WNT3	Proto-oncogene protein Wnt-3 precursor; Ligand for members of the frizzled family of seven tran [...] (355 aa)		•	•	0.946
	WNT10B	Protein Wnt-10b precursor (Wnt-12); Ligand for members of the frizzled family of seven transmem [...] (389 aa)		•	•	0.943

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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