node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFNA1 | EPHA1 | ENSSSCP00000006959 | ENSSSCP00000017441 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ephrin type-A receptor 1. | 0.972 |
EFNA1 | EPHA10 | ENSSSCP00000006959 | ENSSSCP00000055217 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | EPH receptor A10. | 0.944 |
EFNA1 | EPHA2 | ENSSSCP00000006959 | ENSSSCP00000003769 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ephrin type-A receptor 2 isoform 1. | 0.998 |
EFNA1 | EPHA3 | ENSSSCP00000006959 | ENSSSCP00000023658 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ephrin type-A receptor 3 isoform X1. | 0.917 |
EFNA1 | EPHA4 | ENSSSCP00000006959 | ENSSSCP00000017193 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | EPH receptor A4. | 0.987 |
EFNA1 | EPHA7 | ENSSSCP00000006959 | ENSSSCP00000053115 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Ephrin type-A receptor 7 isoform 1. | 0.946 |
EFNA1 | EPHA8 | ENSSSCP00000006959 | ENSSSCP00000003824 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | EPH receptor A8. | 0.902 |
EFNA1 | EPHB4 | ENSSSCP00000006959 | ENSSSCP00000008197 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | EPH receptor B4. | 0.906 |
EFNA1 | FYN | ENSSSCP00000006959 | ENSSSCP00000004770 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | 0.914 |
EFNA1 | RASA1 | ENSSSCP00000006959 | ENSSSCP00000060406 | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | RAS p21 protein activator 1. | 0.912 |
EPHA1 | EFNA1 | ENSSSCP00000017441 | ENSSSCP00000006959 | Ephrin type-A receptor 1. | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | 0.972 |
EPHA1 | EPHA10 | ENSSSCP00000017441 | ENSSSCP00000055217 | Ephrin type-A receptor 1. | EPH receptor A10. | 0.557 |
EPHA1 | EPHA2 | ENSSSCP00000017441 | ENSSSCP00000003769 | Ephrin type-A receptor 1. | Ephrin type-A receptor 2 isoform 1. | 0.810 |
EPHA1 | EPHA3 | ENSSSCP00000017441 | ENSSSCP00000023658 | Ephrin type-A receptor 1. | Ephrin type-A receptor 3 isoform X1. | 0.605 |
EPHA1 | EPHA4 | ENSSSCP00000017441 | ENSSSCP00000017193 | Ephrin type-A receptor 1. | EPH receptor A4. | 0.604 |
EPHA1 | EPHA7 | ENSSSCP00000017441 | ENSSSCP00000053115 | Ephrin type-A receptor 1. | Ephrin type-A receptor 7 isoform 1. | 0.608 |
EPHA1 | EPHB4 | ENSSSCP00000017441 | ENSSSCP00000008197 | Ephrin type-A receptor 1. | EPH receptor B4. | 0.592 |
EPHA1 | RASA1 | ENSSSCP00000017441 | ENSSSCP00000060406 | Ephrin type-A receptor 1. | RAS p21 protein activator 1. | 0.913 |
EPHA10 | EFNA1 | ENSSSCP00000055217 | ENSSSCP00000006959 | EPH receptor A10. | Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] | 0.944 |
EPHA10 | EPHA1 | ENSSSCP00000055217 | ENSSSCP00000017441 | EPH receptor A10. | Ephrin type-A receptor 1. | 0.557 |