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EFNA1 EFNA1 EPHA2 EPHA2 EPHA4 EPHA4 EPHA1 EPHA1 EPHA7 EPHA7 EPHA10 EPHA10 EPHA3 EPHA3 FYN FYN RASA1 RASA1 EPHB4 EPHB4 EPHA8 EPHA8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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EFNA1Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] (205 aa)    
Predicted Functional Partners:
EPHA2
Ephrin type-A receptor 2 isoform 1.
   
 0.998
EPHA4
EPH receptor A4.
   
 0.987
EPHA1
Ephrin type-A receptor 1.
   
 0.972
EPHA7
Ephrin type-A receptor 7 isoform 1.
   
 0.946
EPHA10
EPH receptor A10.
   
 0.944
EPHA3
Ephrin type-A receptor 3 isoform X1.
   
 0.917
FYN
Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...]
   
 0.914
RASA1
RAS p21 protein activator 1.
     
 0.912
EPHB4
EPH receptor B4.
   
 0.906
EPHA8
EPH receptor A8.
   
 0.902
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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