VAC14 protein (Homo sapiens) - STRING network view

STRING 9.05

VAC14 protein (Homo sapiens) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	VAC14	Vac14 homolog (S. cerevisiae); The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes (782 aa)
		(Homo sapiens)
Predicted Functional Partners:
	FIG4	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae); The PI(3,5)P2 regulator [...] (907 aa)	•	•	•	•	0.998
	PIKFYVE	phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates bot [...] (2098 aa)		•	•	•	0.990
	MTM1	myotubularin 1; Dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserin [...] (603 aa)			•	•	0.933
	MTMR2	myotubularin related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgrou [...] (643 aa)			•	•	0.933
	SACM1L	SAC1 suppressor of actin mutations 1-like (yeast); Phosphoinositide phosphatase that hydrolyzes [...] (587 aa)	•		•	•	0.921
	MTMR7	myotubularin related protein 7; Phosphatase that acts on lipids with a phosphoinositol headgrou [...] (660 aa)			•	•	0.916
	MTMR4	myotubularin related protein 4; Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr r [...] (1195 aa)			•	•	0.914
	INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa; Catalyzes the hydrolysis of the 4-positio [...] (977 aa)			•	•	0.900
	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa; Catalyzes the hydrolysis of the 4-positi [...] (924 aa)			•		0.899
	CNTN2	contactin 2 (axonal); May play a role in the initial growth and guidance of axons. May be invol [...] (1040 aa)		•		•	0.809

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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