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erg11 erg11 erg24 erg24 erg7 erg7 erg25 erg25 erg6 erg6 erg4 erg4 erg26 erg26 erg27 erg27 erg9 erg9 erg2 erg2 erg1 erg1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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Score
erg11Lanosterol 14-alpha demethylase erg11; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol. (495 aa)    
Predicted Functional Partners:
erg24
Delta(14)-sterol reductase; Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta- 8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. Belongs to the ERG4/ERG24 family.
   
 0.999
erg7
Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
 
 0.999
erg25
Methylsterol monooxygenase; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family.
   
 
 0.999
erg6
Sterol 24-C-methyltransferase erg6; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of lanosterol to form eburicol (Probable). Involved in the biosynthesis or ergosterol which is important for plasma membrane structure and function and for localization of plasma membrane proteins.
   
 
 0.998
erg4
Delta(24(24(1)))-sterol reductase.
   
 0.998
erg26
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Belongs to the 3-beta-HSD family.
 
 
 0.997
erg27
3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols.
  
 
 0.997
erg9
Squalene synthase; Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol; Belongs to the phytoene/squalene synthase family.
 
 
 0.997
erg2
C-8 sterol isomerase erg2; Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols. Involved in the biosynthesis or ergosterol which is important for plasma membrane structure and function and for localization of plasma membrane proteins.
   
 
 0.996
erg1
Probable squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
  
 0.996
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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