STRINGSTRING
STK11 STK11 STRADA STRADA CAB39 CAB39 CAB39L CAB39L PRKAB1 PRKAB1 PRKAG2 PRKAG2 PRKAA1 PRKAA1 PRKAA2 PRKAA2 PRKAB2 PRKAB2 STRADB STRADB FOXO3 FOXO3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
STK11Serine/threonine-protein kinase STK11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity (By similarity). (426 aa)    
Predicted Functional Partners:
STRADA
STE20-related kinase adapter protein alpha; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).
   
 0.997
CAB39
Calcium binding protein 39.
    
 0.970
CAB39L
Uncharacterized protein.
    
 0.970
PRKAB1
5'AMP-activated protein kinase beta-1 non-catalytic subunit.
    
 0.962
PRKAG2
Uncharacterized protein.
    
 0.956
PRKAA1
Non-specific serine/threonine protein kinase.
   
0.956
PRKAA2
Non-specific serine/threonine protein kinase.
    
0.955
PRKAB2
5'-AMP-activated protein kinase beta-2 non-catalytic subunit transcript variant 2.
    
 0.953
STRADB
STE20 related adaptor beta.
   
 0.949
FOXO3
Forkhead box O3.
    
 0.937
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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