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This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
Il6
interleukin 6; IL-6 is a cytokine with a wide variety of biological functions- it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants (211 aa)
(Mus musculus)
Predicted Functional Partners:
Il6ra
interleukin 6 receptor, alpha; Part of the receptor for interleukin 6. Binds to IL6 with low af [...] (460 aa)
    ••• 0.999
Il6st
interleukin 6 signal transducer; Signal-transducing molecule. The receptor systems for IL6, LIF [...] (917 aa)
    ••• 0.999
Csf2
colony stimulating factor 2 (granulocyte-macrophage); Cytokine that stimulates the growth and d [...] (141 aa)
      • 0.991
Il4
interleukin 4; Participates in at least several B-cell activation processes as well as of other [...] (140 aa)
      • 0.990
Il11
interleukin 11; Directly stimulates the proliferation of hematopoietic stem cells and megakaryo [...] (198 aa)
     •• 0.988
Csf3
colony stimulating factor 3 (granulocyte); Granulocyte/macrophage colony-stimulating factors ar [...] (208 aa)
     •• 0.988
Lif
leukemia inhibitory factor; LIF has the capacity to induce terminal differentiation in leukemic [...] (203 aa)
     •• 0.986
Il12b
interleukin 12b; Cytokine that can act as a growth factor for activated T and NK cells, enhance [...] (335 aa)
     •• 0.984
Il23a
interleukin 23, alpha subunit p19; Associates with IL12B to form the IL-23 interleukin, an hete [...] (196 aa)
     •• 0.983
Il1b
interleukin 1 beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation [...] (269 aa)
      • 0.979
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.
Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:
additional (white) nodes         or: network depth