CYB5R3 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CYB5R3

NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. (379 aa)

Predicted Functional Partners:

CYB5A

0.977

SUOX

0.944

DPYD

0.877

DHODH

0.876

UMPS

0.864

ENSCAFP00000055367

0.801

IYD

0.755

CAD

0.657

TMEM116

0.655

GPR143

0.655

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAD	CYB5R3	ENSCAFP00000039642	ENSCAFP00000039720	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	0.657
CAD	DHODH	ENSCAFP00000039642	ENSCAFP00000044282	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	0.909
CAD	DPYD	ENSCAFP00000039642	ENSCAFP00000029730	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family.	0.826
CAD	UMPS	ENSCAFP00000039642	ENSCAFP00000018290	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	Uridine monophosphate synthetase.	0.916
CYB5A	CYB5R3	ENSCAFP00000000041	ENSCAFP00000039720	Cytochrome b5A microsomal variant; Belongs to the cytochrome b5 family.	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	0.977
CYB5A	SUOX	ENSCAFP00000000041	ENSCAFP00000065414	Cytochrome b5A microsomal variant; Belongs to the cytochrome b5 family.	Sulfite oxidase.	0.551
CYB5R3	CAD	ENSCAFP00000039720	ENSCAFP00000039642	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	0.657
CYB5R3	CYB5A	ENSCAFP00000039720	ENSCAFP00000000041	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	Cytochrome b5A microsomal variant; Belongs to the cytochrome b5 family.	0.977
CYB5R3	DHODH	ENSCAFP00000039720	ENSCAFP00000044282	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	0.876
CYB5R3	DPYD	ENSCAFP00000039720	ENSCAFP00000029730	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family.	0.877
CYB5R3	ENSCAFP00000055367	ENSCAFP00000039720	ENSCAFP00000055367	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	Uncharacterized protein.	0.801
CYB5R3	GPR143	ENSCAFP00000039720	ENSCAFP00000045974	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	G protein-coupled receptor 143.	0.655
CYB5R3	IYD	ENSCAFP00000039720	ENSCAFP00000000578	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	Iodotyrosine deiodinase.	0.755
CYB5R3	SUOX	ENSCAFP00000039720	ENSCAFP00000065414	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	Sulfite oxidase.	0.944
CYB5R3	TMEM116	ENSCAFP00000039720	ENSCAFP00000012891	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	Transmembrane protein 116.	0.655
CYB5R3	UMPS	ENSCAFP00000039720	ENSCAFP00000018290	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	Uridine monophosphate synthetase.	0.864
DHODH	CAD	ENSCAFP00000044282	ENSCAFP00000039642	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	0.909
DHODH	CYB5R3	ENSCAFP00000044282	ENSCAFP00000039720	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.	0.876
DHODH	GPR143	ENSCAFP00000044282	ENSCAFP00000045974	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	G protein-coupled receptor 143.	0.834
DHODH	TMEM116	ENSCAFP00000044282	ENSCAFP00000012891	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	Transmembrane protein 116.	0.834

page 1 of 3

Server load: low (10%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2023

Credits

Access

Info

About