Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13); Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 exp [...] (393 aa)

Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Do [...] (491 aa)

Histone acetyltransferase p300 (EC 2.3.1.48) (E1A-associated protein p300); Functions as histon [...] (2414 aa)

Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated); Serine/ [...] (3056 aa)

Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.1.2.15) (Ubiquitin thioesterase 7) (Ubiquitin-spe [...] (1110 aa)

Breast cancer type 1 susceptibility protein (RING finger protein 53); Plays a central role in D [...] (1863 aa)

Cyclin-dependent kinase inhibitor 1 (p21) (CDK-interacting protein 1) (Melanoma differentiation [...] (164 aa)

Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member [...] (826 aa)

Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double [...] (490 aa)

Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1); May have a rol [...] (1972 aa)

CREB-binding protein (EC 2.3.1.48); Acetylates histones, giving a specific tag for transcriptio [...] (2472 aa)